ArticleScientific reports2020
Fungal secretome profile categorization of CAZymes by function and family corresponds to fungal phylogeny and taxonomy: Example Aspergillus and Penicillium.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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43 citing papers in PubMed.
- What makes a mycoparasite? Candidate effectors from fungi that parasitize other fungi exhibit structural homology to those of fungal plant pathogens.Fungal biology and biotechnology · 2026Article
- CAZome comparison in relation to host plant for selectedFrontiers in fungal biology · 2026Article
- Phylogenetic analysis of xylan-degrading hemicellulases fromFrontiers in microbiology · 2026Article
- From chaos to tranquillity: a modern approach to the identification, nomenclature and phylogeny ofStudies in mycology · 2025Article
- Genomic insights into the virulence repertoire and hemibiotrophic lifestyle of the grapevine black rot pathogen Phyllosticta ampelicida.G3 (Bethesda, Md.) · 2025Article
- Organic matter degradation by oceanic fungi differs between polar and non-polar waters.Nature communications · 2025Article
- Genome assembly and comparative analysis of Alternaria Linariae reveal novel genes associated with host colonization and virulence.BMC genomics · 2025Article
- Improving recombinant protein secretion inMetabolic engineering communications · 2025Article
- A Chromosome-Scale Genome ofJournal of fungi (Basel, Switzerland) · 2025Article
- Hybrid assembly ofIMA fungus · 2025Article
- Unraveling the genetic basis of methane emission in dairy cattle: a comprehensive exploration and breeding approach to lower methane emissions.Animal biotechnology · 2024Review
- Comparative genomics of Metarhizium brunneum strains V275 and ARSEF 4556: unraveling intraspecies diversity.G3 (Bethesda, Md.) · 2024Article
- Comparative Genomics of Fungi in Nectriaceae Reveals Their Environmental Adaptation and Conservation Strategies.Journal of fungi (Basel, Switzerland) · 2024Article
- Genomic Sequencing and Functional Analysis of the Ex-Type Strain ofJournal of fungi (Basel, Switzerland) · 2024Article
- Review
- What are the 100 most cited fungal genera?Studies in mycology · 2024Article
- Secretome Analysis ofJournal of fungi (Basel, Switzerland) · 2024Article
- DNA isolation and genome sequence of the 134-year-old holotype specimen ofEcology and evolution · 2023Article
- Quantification of Xylanolytic and Cellulolytic Activities of Fungal Strains Isolated fromMarine drugs · 2023Article
- The InvasivePlants (Basel, Switzerland) · 2023Article
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5 authors.
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Abstract
Fungi secrete an array of carbohydrate-active enzymes (CAZymes), reflecting their specialized habitat-related substrate utilization. Despite its importance for fitness, enzyme secretome composition is not used in fungal classification, since an overarching relationship between CAZyme profiles and fungal phylogeny/taxonomy has not been established. For 465 Ascomycota and Basidiomycota genomes, we predicted CAZyme-secretomes, using a new peptide-based annotation method, Conserved-Unique-Peptide-Patterns, enabling functional prediction directly from sequence. We categorized each enzyme according to CAZy-family and predicted molecular function, hereby obtaining a list of "EC-Function;CAZy-Family" observations. These "Function;Family"-based secretome profiles were compared, using a Yule-dissimilarity scoring algorithm, giving equal consideration to the presence and absence of individual observations. Assessment of "Function;Family" enzyme profile relatedness (EPR) across 465 genomes partitioned Ascomycota from Basidiomycota placing Aspergillus and Penicillium among the Ascomycota. Analogously, we calculated CAZyme "Function;Family" profile-similarities among 95 Aspergillus and Penicillium species to form an alignment-free, EPR-based dendrogram. This revealed a stunning congruence between EPR categorization and phylogenetic/taxonomic grouping of the Aspergilli and Penicillia. Our analysis suggests EPR grouping of fungi to be defined both by "shared presence" and "shared absence" of CAZyme "Function;Family" observations. This finding indicates that CAZymes-secretome evolution is an integral part of fungal speciation, supporting integration of cladogenesis and anagenesis.
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