ArticleScientific reports2020
Increased male susceptibility to Mycobacterium tuberculosis infection is associated with smaller B cell follicles in the lungs.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 55 citations in OpenAlex.
- Article
- Risk Factors for Immunological Sensitization to Mycobacterium tuberculosis and Progression to Incident TB Disease Among HIV-uninfected Adults in a High Burden Setting.The Journal of infectious diseases · 2026Article
- Host immunosenescence compromisesAging · 2026Article
- Sex as a Biological Variable in Tuberculosis Pathogenesis.Immunological reviews · 2026Review
- B cells and iBALT in TB immunity & pathogenesis.Frontiers in immunology · 2026Review
- The role of cytochrome bcNature communications · 2025Article
- SMURF2 inhibits autophagic control ofbioRxiv : the preprint server for biology · 2025Article
- Impact of seropositivity and disease-modifying antirheumatic drugs on pulmonary tuberculosis risk in rheumatoid arthritis.ERJ open research · 2025Article
- Characterizing TLR4 agonist EmT4™ as an anti-Mycobacterium tuberculosis vaccine adjuvant.ImmunoHorizons · 2025Article
- Estimation of tuberculosis mortality burden in Spain: a review of the major data sources.ERJ open research · 2025Article
- Sex differences in tuberculosis infection and disease among people with HIV.AIDS (London, England) · 2025Article
- Sex influences murine T cell responses to vaccination with BCG or BCG∆BCG1419 grown as biofilms.Memorias do Instituto Oswaldo Cruz · 2025Article
- Sex-specific impact of B cell-derived IL-10 on tuberculosis resistance.Frontiers in immunology · 2025Article
- Toward understanding sexual immune dimorphism in humans.Frontiers in immunology · 2025Review
- Tertiary lymphoid structures in diseases: immune mechanisms and therapeutic advances.Signal transduction and targeted therapy · 2024Review
- The Influence of Body Fat Dynamics on Pulmonary Immune Responses in Murine Tuberculosis: Unraveling Sex-Specific Insights.International journal of molecular sciences · 2024Article
- B cell heterogeneity in human tuberculosis highlights compartment-specific phenotype and functional roles.Communications biology · 2024Article
- Population structure and spatial distribution of Mycobacterium tuberculosis in Ethiopia.Scientific reports · 2024Article
- The epidemiological situation of tuberculosis in Spain according to surveillance and hospitalization data, 2012-2020.PloS one · 2024Article
- Protective interplay:Frontiers in immunology · 2024Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tuberculosis prevalence is significantly higher among men than women. We have previously revealed an increased susceptibility of male C57BL/6 mice towards Mycobacterium tuberculosis (Mtb) H37Rv. In the current study, we confirm the male bias for infection with the Beijing strain HN878. Males succumbed to HN878 infection significantly earlier than females. In both models, premature death of males was associated with smaller B cell follicles in the lungs. Analysis of homeostatic chemokines and their receptors revealed differences between H37Rv and HN878 infected animals, indicating different immune requirements for follicle formation in both models. However, expression of IL-23, which is involved in long-term containment of Mtb and lymphoid follicle formation, was reduced in male compared to female lungs in both models. Our study reveals sex differences in the formation of B cell follicles in the Mtb infected lung and we propose that impaired follicle formation is responsible for accelerated disease progression in males.
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