ArticleNature communications2020
Protein-polymer bioconjugates via a versatile oxygen tolerant photoinduced controlled radical polymerization approach.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- Oxygen-Tolerant Photo-Induced Miniaturized Accelerated Atom Transfer Radical Polymerization (OPTIMA-ATRP) for High-Throughput Synthesis of Polymer Bioconjugates.Angewandte Chemie (International ed. in English) · 2026Article
- Photocatalytic Depolymerization of Commercial Polymethacrylates via a Solvent-Independent Pathway.Journal of the American Chemical Society · 2026Article
- Heterogeneous photocatalyst enables large-scale broadband light-driven atom transfer radical polymerization with high oxygen and inhibitor tolerance.Nature communications · 2026Article
- Reversible Deactivation Radical Polymerization in Biomass-Derived Solvents: Sustainable Approach in Polymer Chemistry.ACS polymers Au · 2025Review
- Photo-excited extracellular electron transfer of electroactive microorganism triggers RAFT polymerization.Nature communications · 2025Article
- Site-Specific Polymer-Protein-Polymer Conjugates for the Preparation of Dual Responsive Multilayer Nanoparticles.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Machine Learning in Polymer Research.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Review
- Artificial Zymogen Based on Protein-Polymer Hybrids.Biomacromolecules · 2024Article
- Protein Corona of Nanoparticles: Isolation and Analysis.Chem & bio engineering · 2024Review
- Sequence-encoded bioactive protein-multiblock polymer conjugates via quantitative one-pot iterative living polymerization.Nature communications · 2024Article
- Aerobic mechanochemical reversible-deactivation radical polymerization.Nature communications · 2024Article
- Open-Air Chemical Recycling: Fully Oxygen-Tolerant ATRP Depolymerization.Journal of the American Chemical Society · 2024Article
- Aqueous photo-RAFT polymerization under ambient conditions: synthesis of protein-polymer hybrids in open air.Chemical science · 2024Article
- Nucleic Acid-Binding Dyes as Versatile Photocatalysts for Atom-Transfer Radical Polymerization.Journal of the American Chemical Society · 2024Article
- The lactate-to-albumin ratio relationship with all-cause mortality in cerebral infarction patients: analysis from the MIMIC-IV database.Frontiers in neurology · 2024Article
- Fate of the RAFT End-Group in the Thermal Depolymerization of Polymethacrylates.ACS macro letters · 2023Article
- Carbon-Centered Radicals in Protein Manipulation.ACS central science · 2023Review
- Fully Oxygen-Tolerant Visible-Light-Induced ATRP of Acrylates in Water: Toward Synthesis of Protein-Polymer Hybrids.Macromolecules · 2023Article
- Light-accelerated depolymerization catalyzed by Eosin Y.Polymer chemistry · 2023Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The immense application potential of amphiphilic protein-polymer conjugates remains largely unexplored, as established "grafting from" synthetic protocols involve time-consuming, harsh and disruptive deoxygenation methods, while "grafting to" approaches result in low yields. Here we report an oxygen tolerant, photoinduced CRP approach which readily affords quantitative yields of protein-polymer conjugates within 2 h, avoiding damage to the secondary structure of the protein and providing easily accessible means to produce biomacromolecular assemblies. Importantly, our methodology is compatible with multiple proteins (e.g. BSA, HSA, GOx, beta-galactosidase) and monomer classes including acrylates, methacrylates, styrenics and acrylamides. The polymerizations are conveniently conducted in plastic syringes and in the absence of any additives or external deoxygenation procedures using low-organic content media and ppm levels of copper. The robustness of the protocol is further exemplified by its implementation under UV, blue light or even sunlight irradiation as well as in buffer, nanopure, tap or even sea water.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.