Evidence map›Paper›PMID 32198361›Full record

SynthesisTranslational psychiatry2020

ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries.

Paul M Thompson, Neda Jahanshad, Christopher R K Ching, Lauren E Salminen, Sophia I Thomopoulos, Joanna Bright, Bernhard T Baune, Sara Bertolín, Janita Bralten, Willem B Bruin and 161 more

Registry-linked trialOpen access · goldAbstract readMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Translational psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05890768 (The Relationship Between the Efficacy of Lumateperone and Central Glutamate and Dopaminergic Metabolism), which is not on this map. Cited by 400 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
400citing papers in PubMed, 14 pooled it
45.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05890768 phase4withdrawnnot on this mapstarted 2023, after this paper: background citation

The Relationship Between the Efficacy of Lumateperone and Central Glutamate and Dopaminergic Metabolism: A Comparison With Risperidone in First Episode Psychosis

TypeinterventionalSponsorUniversity of New MexicoRan2023 to 2024Enrolled0ConditionsPsychosisArmsLumateperone, Risperidone
3 · Its place in the literature

Who cites it

400 citing papers in PubMed, 14 syntheses or guidelines pooled it, 660 citations in OpenAlex.

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  16. Big data and psychiatry: advances, constraints and future directions.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2026
    Article
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340 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

171 authors at 20 institutions in 20 countries.

Paul M ThompsonImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA. pthomp@usc.edu.
Neda JahanshadImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.ORCID http://orcid.org/0000-0003-4401-8950
Christopher R K ChingImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
Lauren E SalminenImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.ORCID http://orcid.org/0000-0002-0684-9991
Sophia I ThomopoulosImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.ORCID http://orcid.org/0000-0002-0046-4070
Joanna BrightImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
Bernhard T BauneDepartment of Psychiatry, University of Münster, Münster, Germany.
Sara BertolínDepartment of Psychiatry, Bellvitge University Hospital, Bellvitge Biomedical Research Institute-IDIBELL, Barcelona, Spain.
Janita BraltenDepartment of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands.
Willem B BruinDepartment of Psychiatry, Amsterdam UMC, University of Amsterdam, Amsterdam Neuroscience, Amsterdam, The Netherlands.
Robin BülowInstitute for Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany.
Jian ChenDepartment of Computer Science and Engineering, The Ohio State University, Columbus, OH, USA.
Yann ChyeTurner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Clayton, VIC, Australia.
Udo DannlowskiDepartment of Psychiatry, University of Münster, Münster, Germany.
Carolien G F de KovelBiometris Wageningen University and Research, Wageningen, The Netherlands.
Gary DonohoeThe Center for Neuroimaging and Cognitive Genomics, School of Psychology, National University of Ireland, Galway, Ireland.
Lisa T EylerDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
Stephen V FaraoneDepartments of Psychiatry and of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, NY, USA.
Pauline FavreINSERM Unit 955 Team 15 'Translational Psychiatry', Créteil, France.
Courtney A FilippiNational Institute of Mental Health, National of Health, Bethesda, MD, USA.
Thomas FrodlDepartment of Psychiatry and Psychotherapy, Otto von Guericke University Magdeburg, Magdeburg, Germany.
Daniel GarijoInformation Sciences Institute, University of Southern California, Marina del Rey, CA, USA.
Yolanda GilInformation Sciences Institute, University of Southern California, Marina del Rey, CA, USA.
Hans J GrabeDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.
Katrina L GrasbyPsychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Tomas HajekDepartment of Psychiatry, Dalhousie University, Halifax, NS, Canada.
Laura K M HanDepartment of Psychiatry, Amsterdam University Medical Centers, VU University Medical Center, GGZ inGeest, Amsterdam Neuroscience, Amsterdam, The Netherlands.
Sean N HattonCenter for Multimodal Imaging and Genetics, University of California, San Diego, La Jolla, CA, USA.
Kevin HilbertDepartment of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany.
Tiffany C HoDepartment of Psychiatry & Behavioral Sciences, Stanford University, Stanford, CA, USA.
Laurena HolleranThe Center for Neuroimaging and Cognitive Genomics, School of Psychology, National University of Ireland, Galway, Ireland.
Georg HomuthInterfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
Norbert HostenInstitute for Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany.
Josselin HouenouINSERM Unit 955 Team 15 'Translational Psychiatry', Créteil, France.
Iliyan IvanovIcahn School of Medicine at Mount Sinai, New York, NY, USA.
Tianye JiaInstitute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China.
Sinead KellyDepartment of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Marieke KleinDepartment of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands.
Jun Soo KwonDepartment of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea.
Max A LaansmaDepartment of Anatomy & Neurosciences, Amsterdam UMC, Location VUmc, Amsterdam Neuroscience, Amsterdam, The Netherlands.
Jeanne LeerssenDepartment of Sleep and Cognition, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands.
Ulrike LuekenDepartment of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany.
Abraham NunesDepartment of Psychiatry, Dalhousie University, Halifax, NS, Canada.
Joseph O' NeillChild & Adolescent Psychiatry, University of California, Los Angeles, Los Angeles, CA, USA.
Nils OpelDepartment of Psychiatry, University of Münster, Münster, Germany.
Fabrizio PirasLaboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy.
Federica PirasLaboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy.
Merel C PostemaLanguage & Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands.
Elena PozziMelbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Melbourne, VIC, Australia.
Natalia ShatokhinaImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
Carles Soriano-MasDepartment of Psychiatry, Bellvitge University Hospital, Bellvitge Biomedical Research Institute-IDIBELL, Barcelona, Spain.
Gianfranco SpallettaLaboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy.
Daqiang SunDepartment of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA.
Alexander TeumerInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Amanda K TilotImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
Leonardo TozziDepartment of Psychiatry & Behavioral Sciences, Stanford University, Stanford, CA, USA.
Celia van der MerweStanley Center for Psychiatric Research, The Broad Institute, Cambridge, MA, USA.
Eus J W Van SomerenDepartment of Sleep and Cognition, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands.
Guido A van WingenDepartment of Psychiatry, Amsterdam UMC, University of Amsterdam, Amsterdam Neuroscience, Amsterdam, The Netherlands.
Henry VölzkeInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Esther WaltonDepartment of Psychology, University of Bath, Bath, UK.
Lei WangPsychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Anderson M WinklerNational Institute of Mental Health, National of Health, Bethesda, MD, USA.
Katharina WittfeldDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.
Margaret J WrightQueensland Brain Institute, University of Queensland, Brisbane, QLD, Australia.
Je-Yeon YunSeoul National University Hospital, Seoul, Republic of Korea.
Guohao ZhangDepartment of Computer Science and Electrical Engineering, University of Maryland, Baltimore County, MD, USA.
Yanli Zhang-JamesDepartments of Psychiatry and of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, NY, USA.
Bhim M AdhikariDepartment of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.
Ingrid AgartzNorwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health & Addiction, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Moji AghajaniDepartment of Psychiatry, Amsterdam UMC, Location VUmc, Amsterdam Neuroscience, Amsterdam, The Netherlands.
André AlemanUniversity of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Robert R AlthoffPsychiatry, Pediatrics, and Psychological Sciences, University of Vermont, Burlington, VT, USA.
Andre AltmannCentre for Medical Image Computing (CMIC), Department of Medical Physics and Biomedical Engineering, University College London, London, UK.
Ole A AndreassenNorwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health & Addiction, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
David A BaronProvost and Senior Vice President, Western University of Health Sciences, Pomona, CA, USA.
Brenda L Bartnik-OlsonDepartment of Radiology, Loma Linda University Medical Center, Loma Linda, CA, USA.
Janna Marie Bas-HoogendamInstitute of Psychology, Leiden University, Leiden, The Netherlands.
Arielle R Baskin-SommersDepartment of Psychology, Yale University, New Haven, CT, USA.
Carrie E BeardenDepartment of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA.
Laura A BernerIcahn School of Medicine at Mount Sinai, New York, NY, USA.
Premika S W BoedhoeDepartment of Psychiatry, Amsterdam UMC, Location VUmc, Amsterdam Neuroscience, Amsterdam, The Netherlands.
Rachel M BrouwerDepartment of Psychiatry, UMC Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Jan K BuitelaarDepartment of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.
Karen CaeyenberghsCognitive Neuroscience Unit, School of Psychology, Deakin University, Burwood, VIC, Australia.
Charlotte A M CecilDepartment of Child and Adolescent Psychiatry/Psychology, Erasmus Medical Centre, Rotterdam, The Netherlands.
Ronald A CohenCenter for Cognitive Aging and Memory, University of Florida, Gainesville, FL, USA.
James H ColeCentre for Medical Image Computing (CMIC), Department of Computer Science, University College London, London, UK.
Patricia J ConrodUniversite de Montreal, Centre de Recherche CHU Ste-Justine, Montreal, QC, Canada.
Stephane A De BritoSchool of Psychology and Centre for Human Brain Health, University of Birmingham, Birmingham, UK.
Sonja M C de ZwarteDepartment of Psychiatry, UMC Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Emily L DennisImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
Sylvane DesrivieresSocial, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Danai DimaDepartment of Psychology, School of Arts and Social Sciences, City, University of London, London, UK.
Stefan EhrlichDivision of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, TU Dresden, Dresden, Germany.
Carrie EsopenkoDepartment of Rehabilitation and Movement Sciences, School of Health Professions, Rutgers Biomedical Health Sciences, Newark, NJ, USA.
Graeme FairchildDepartment of Psychology, University of Bath, Bath, UK.
Simon E FisherDonders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.
Jean-Paul FoucheDepartment of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.
Clyde FrancksDonders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.
Sophia FrangouDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Barbara FrankeDepartment of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands.
Hugh P GaravanDepartment of Psychiatry, University of Vermont, Burlington, VT, USA.
David C GlahnDepartment of Psychiatry, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.
Nynke A GroenewoldDepartment of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.
Tiril P GurholtNorwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health & Addiction, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Boris A GutmanBiomedical Engineering, Illinois Institute of Technology, Chicago, IL, USA.
Tim HahnDepartment of Psychiatry, University of Münster, Münster, Germany.
Ian H HardingTurner Institute for Brain and Mental Health & School of Psychological Sciences, Monash University, Melbourne, VIC, Australia.
Dennis HernausDepartment of Psychiatry & Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands.
Derrek P HibarGenentech, Inc., South San Francisco, CA, USA.
Frank G HillaryDepartment of Psychology, Penn State University, University Park, PA, USA.
Martine HoogmanDepartment of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands.
Hilleke E Hulshoff PolDepartment of Psychiatry, UMC Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Maria JalbrzikowskiDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
George A KarkashadzeResearch and Scientific Institute of Pediatrics and Child Health, CCH RAS, Ministry of Science and Higher Education, Moscow, Russian Federation.
Eduard T KlapwijkInstitute of Psychology, Leiden University, Leiden, The Netherlands.
Rebecca C KnickmeyerDepartment of Pediatrics, Michigan State University, East Lansing, MI, USA.
Peter KochunovDepartment of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.
Inga K KoertePsychiatry Neuroimaging Laboratory, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA.
Xiang-Zhen KongLanguage & Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands.
Sook-Lei LiewStevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Alexander P LinCenter for Clinical Spectroscopy, Brigham and Women's Hospital, Boston, MA, USA.
Mark W LogueNational Center for PTSD at Boston VA Healthcare System, Boston, MA, USA.
Eileen LudersSchool of Psychology, University of Auckland, Auckland, New Zealand.
Fabio MacciardiDepartment of Psychiatry and Human Behavior, University of California, Irvine, Irvine, CA, USA.
Scott MackeyDepartment of Psychiatry, University of Vermont, Burlington, VT, USA.
Andrew R MayerMind Research Network, Albuquerque, NM, USA.
Carrie R McDonaldCenter for Multimodal Imaging and Genetics, University of California, San Diego, La Jolla, CA, USA.
Agnes B McMahonImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
Sarah E MedlandPsychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Gemma ModinosDepartment of Neuroimaging, Institute of Psychology, Psychiatry and Neurosciences, King's College London, London, UK.
Rajendra A MoreyDepartment of Psychiatry, Duke University School of Medicine, Durham, NC, USA.
Sven C MuellerExperimental Clinical & Health Psychology, Ghent University, Ghent, Belgium.
Pratik MukherjeeRadiology and Biomedical Imaging, San Francisco, CA, USA.
Leyla Namazova-BaranovaResearch and Scientific Institute of Pediatrics and Child Health, CCH RAS, Ministry of Science and Higher Education, Moscow, Russian Federation.
Talia M NirImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
Alexander OlsenDepartment of Psychology, Norwegian University of Science and Technology, Trondheim, Norway.
Peristera PaschouBiological Sciences, Purdue University, West Lafayette, IN, USA.
Daniel S PineNational Institute of Mental Health Intramural Research Program, Bethesda, MD, USA.
Fabrizio PizzagalliImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
Miguel E RenteríaDepartment of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Jonathan D RohrerDepartment of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK.
Philipp G SämannMax Planck Institute of Psychiatry, Munich, Germany.
Lianne SchmaalOrygen, The National Centre of Excellence in Youth Mental Health, Melbourne, VIC, Australia.
Gunter SchumannCentre for Population Neuroscience and Precision Medicine (PONS), MRC SGDP Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Mark S ShiroishiImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
Sanjay M SisodiyaDepartment of Clinical and Experimental Epilepsy, University College London, London, UK.
Dirk J A SmitDepartment of Psychiatry, Amsterdam UMC, University of Amsterdam, Amsterdam Neuroscience, Amsterdam, The Netherlands.
Ida E SønderbyNorwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health & Addiction, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Dan J SteinDepartment of Psychiatry & Neuroscience Institute, SA MRC Unit on Risk & Resilience in Mental Disorders, Cape Town, South Africa.
Jason L SteinDepartment of Genetics & UNC Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Masoud TahmasianInstitute of Medical Science and Technology, Shahid Beheshti University, Tehran, I. R., Iran.
David F TateDepartment of Neurology, TBI and Concussion Center, Salt Lake City, UT, USA.
Jessica A TurnerPsychology Department & Neuroscience Institute, Georgia State University, Atlanta, GA, USA.
Odile A van den HeuvelDepartment of Anatomy & Neurosciences, Amsterdam UMC, Location VUmc, Amsterdam Neuroscience, Amsterdam, The Netherlands.
Nic J A van der WeeDepartment of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands.
Ysbrand D van der WerfDepartment of Anatomy & Neurosciences, Amsterdam UMC, Location VUmc, Amsterdam Neuroscience, Amsterdam, The Netherlands.
Theo G M van ErpClinical Translational Neuroscience Laboratory, Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA, USA.
Neeltje E M van HarenDepartment of Psychiatry, UMC Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Daan van RooijDonders Centre for Cognitive Neuroimaging, Radboud University Medical Centre, Nijmegen, The Netherlands.
Laura S van VelzenOrygen, The National Centre of Excellence in Youth Mental Health, Melbourne, VIC, Australia.
Ilya M VeerDivision of Mind and Brain Research, Department of Psychiatry and Psychotherapy CCM, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Dick J VeltmanDepartment of Psychiatry, Amsterdam UMC, Location VUmc, Amsterdam Neuroscience, Amsterdam, The Netherlands.
Julio E Villalon-ReinaImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
Henrik WalterDivision of Mind and Brain Research, Department of Psychiatry and Psychotherapy CCM, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Christopher D WhelanMolecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland.
Elisabeth A WildeDepartment of Neurology, University of Utah, Salt Lake City, UT, USA.
Mojtaba ZareiInstitute of Medical Science and Technology, Shahid Beheshti University, Tehran, I. R., Iran.
Vladimir ZelmanKeck School of Medicine, University of Southern California, Los Angeles, CA, USA.
ENIGMA Consortium
University of Southern California · USAmsterdam Neuroscience · NLRadboud University Nijmegen · NLUniversitätsmedizin Greifswald · DEHumboldt-Universität zu Berlin · DEKing's College London · GBThe University of Melbourne · AUUtrecht University · NLBrigham and Women's Hospital · USMax Planck Institute for Psycholinguistics · NLNational Institute of Mental Health · USOslo University Hospital · NOQIMR Berghofer Medical Research Institute · AUUniversity of California, Los Angeles · USUniversity of Münster · DEUniversity of Vermont · USBaylor College of Medicine · USDalhousie University · CAFondazione Santa Lucia · ITIcahn School of Medicine at Mount Sinai · US

Funding

Training U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1M
Neurodevelopment and Psychosis in the 22q11.2 Deletion SyndromeR01MH085953 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BEARDEN, CARRIE E · 2010 to 2020
$6.2M
ENIGMA- Addiction: Pooling of Existing Datasets to Identify Brain and Genetic Correlates of Addiction, Next StepsR01DA047119 · NIDA · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI HUGH P. GARAVAN · 2018 to 2026
$5.4M
SOLAR-Eclipse Computational Tools for Imaging GeneticsR01EB015611 · NIBIB · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI KOCHUNOV, PETER V. · 2012 to 2024
$5.0M
Trauma and Genomics Modulate Brain Structure across Common Psychiatric DisordersR01MH111671 · NIMH · DUKE UNIVERSITY · PI MARK W LOGUE, RAJENDRA A MOREY · 2017 to 2026
$4.4M
Amish Connectome Project on Mental IllnessU01MH108148 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI HONG, L ELLIOT ELLIOT, KOCHUNOV, PETER V. · 2015 to 2018
$4.3M
Supplement to Effects of global brain health on sensorimotor recovery after strokeR01NS115845 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI LIEW, SOOK-LEI · 2020 to 2024
$3.2M
High resolution mapping of the genetic risk for disease in the aging brainR01AG059874 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JAHANSHAD, NEDA · 2018 to 2022
$3.1M
ENIGMA-SD: Understanding Sex Differences in Global Mental Health through ENIGMAR01MH116147 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2018 to 2021
$2.5M
Training in the Multiscale and Multimodal Analysis of Biomarkers in Alzheimer’s DiseaseT32AG058507 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ARTHUR W TOGA · 2018 to 2026
$2.1M
A global alliance to unlock brain mechanisms influencing suicidal behaviors through the ENIGMA ConsortiumR01MH117601 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JAHANSHAD, NEDA, SCHMAAL, LIANNE · 2018 to 2021
$1.5M
Big Data Neuroimaging to Predict Motor Behavior After StrokeK01HD091283 · NICHD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI LIEW, SOOK-LEI · 2017 to 2020
$802k
Medical Research Council MR/L016311/1Medical Research Council MR/R00465X/1Medical Research Council MR/S020306/1MRF_ MRF-058-0004-RG-DESRIMRF_ MRF-058-0009-RG-DESR-C0759NIA NIH HHS R01 AG059874NIA NIH HHS R56 AG058854NIBIB NIH HHS U54 EB020403NICHD NIH HHS K01 HD091283NIDA NIH HHS R01 DA047119NIH HHS S10 OD023696NIMH NIH HHS R01 MH111671NIMH NIH HHS R01 MH116147NIMH NIH HHS R01 MH117601NINDS NIH HHS R21 NS107739ODCDC CDC HHS S10 OD023696
6 · The paper itself

Abstract

This review summarizes the last decade of work by the ENIGMA (Enhancing NeuroImaging Genetics through Meta Analysis) Consortium, a global alliance of over 1400 scientists across 43 countries, studying the human brain in health and disease. Building on large-scale genetic studies that discovered the first robustly replicated genetic loci associated with brain metrics, ENIGMA has diversified into over 50 working groups (WGs), pooling worldwide data and expertise to answer fundamental questions in neuroscience, psychiatry, neurology, and genetics. Most ENIGMA WGs focus on specific psychiatric and neurological conditions, other WGs study normal variation due to sex and gender differences, or development and aging; still other WGs develop methodological pipelines and tools to facilitate harmonized analyses of "big data" (i.e., genetic and epigenetic data, multimodal MRI, and electroencephalography data). These international efforts have yielded the largest neuroimaging studies to date in schizophrenia, bipolar disorder, major depressive disorder, post-traumatic stress disorder, substance use disorders, obsessive-compulsive disorder, attention-deficit/hyperactivity disorder, autism spectrum disorders, epilepsy, and 22q11.2 deletion syndrome. More recent ENIGMA WGs have formed to study anxiety disorders, suicidal thoughts and behavior, sleep and insomnia, eating disorders, irritability, brain injury, antisocial personality and conduct disorder, and dissociative identity disorder. Here, we summarize the first decade of ENIGMA's activities and ongoing projects, and describe the successes and challenges encountered along the way. We highlight the advantages of collaborative large-scale coordinated data analyses for testing reproducibility and robustness of findings, offering the opportunity to identify brain systems involved in clinical syndromes across diverse samples and associated genetic, environmental, demographic, cognitive, and psychosocial factors.

Indexed as

Major Depressive DisorderBrainHumansMagnetic Resonance ImagingNeuroimagingReproducibility of Results

Identifiers

PMID32198361
PMCPMC7083923
OpenAlexW3012009865

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.