Evidence map›Paper›PMID 32198360›Full record

ArticleScientific reports2020

Low FVC/TLC in Preserved Ratio Impaired Spirometry (PRISm) is associated with features of and progression to obstructive lung disease.

Spyridon Fortis, Alejandro Comellas, Victor Kim, Richard Casaburi, John E Hokanson, James D Crapo, Edwin K Silverman, Emily S Wan

Abstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Definitions of early COPD and predictors for disease progression: a systematic review.European respiratory review : an official journal of the European Respiratory Society · 2026
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  20. Definition and Nomenclature of Chronic Obstructive Pulmonary Disease: Time for Its Revision.American journal of respiratory and critical care medicine · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Spyridon FortisCenter for Access & Delivery Research & Evaluation (CADRE), Iowa City VA Health Care System, Iowa City, IA, USA. spyridon-fortis@uiowa.edu.
Alejandro ComellasDivision of Pulmonary, Critical Care and Occupational Medicine, University of Iowa Hospital and Clinics, Iowa City, IA, USA.
Victor KimDepartment of Thoracic Medicine and Surgery, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.
Richard CasaburiLundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
John E HokansonDepartment of Epidemiology, Colorado School of Public Health, University of Colorado Denver, Denver, CO, USA.
James D CrapoDepartment of Medicine, National Jewish Health, Denver, CO, USA.
Edwin K SilvermanChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Emily S WanChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA.

Funding

Genetic Epidemiology of COPDU01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2007 to 2021
$56.9M
Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI HANS-JOACHIM LEHMLER · 1990 to 2026
$40.5M
Vector Core-Core 2P30DK054759 · NIDDK · UNIVERSITY OF IOWA · PI Amy Leanne Ryan · 1998 to 2026
$30.5M
Genetic Epidemiology of COPDU01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2007 to 2021
$20.7M
The epigenetics of exercise and physical activity in COPDIK2RX002165 · VA · VA BOSTON HEALTH CARE SYSTEM · PI WAN, EMILY S · 2016 to 2021
–
HSRD VA CIN 13-412NHLBI NIH HHS U01 HL089856NHLBI NIH HHS U01 HL089897NIDDK NIH HHS P30 DK054759NIEHS NIH HHS P30 ES005605RRD VA IK2 RX002165
6 · The paper itself

Abstract

One quarter of individuals with Preserved Ratio Impaired Spirometry (PRISm) will develop airflow obstruction, but there are no established methods to identify these individuals. We examined the utility of FVC/TLC in identifying features of obstructive lung disease. The ratio of post-bronchodilator FVC and TLC

Indexed as

AgedDisease ProgressionFemaleForced Expiratory VolumeHumansLungMaleMiddle AgedPulmonary Disease, Chronic ObstructivePulmonary EmphysemaRespiratory Function TestsSpirometryTomography, X-Ray ComputedTotal Lung CapacityVital Capacity

Identifiers

PMID32198360
PMCPMC7083974

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.