ArticleScientific reports2020
The distinctive structure and composition of arterial and venous thrombi and pulmonary emboli.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 155 papers, 3 of them syntheses that pooled it.
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Who cites it
155 citing papers in PubMed, 3 syntheses or guidelines pooled it, 250 citations in OpenAlex.
- Statins for adults with a first episode of venous thromboembolic disease.The Cochrane database of systematic reviews · 2026Pooled it
- COVID-19 and Venous Thromboembolism: A Meta-analysis of Literature Studies.Seminars in thrombosis and hemostasis · 2020Pooled it
- Shell Versus Core Architecture and Biology of Thrombi in Acute Ischemic Stroke: A Systematic Review.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisPooled it
- Zalunfiban at First Medical Contact for ST-Elevation Myocardial Infarction.NEJM evidence · 2026Trial
- Ultrafast shear-wave elastography for pediatric deep vein thrombosis: a prospective feasibility study.Pediatric radiology · 2026Article
- Multivalent Bi-Specific Nanoerythrosomes: A Two-Birds-One-Stone Approach to Combine Homologous and Active Targeting for Effective Thrombolysis.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Von Willebrand factor A1 blockade prevents platelet-mediated sustained occlusion for the treatment of arterial thrombosis.Communications biology · 2026Article
- Arterial shear rate determines the structure and mechanical properties of whole-blood clots.Research and practice in thrombosis and haemostasis · 2026Article
- Visualization of new vessel formation during venous thrombus organization using genetic fate mapping.Research and practice in thrombosis and haemostasis · 2026Article
- The fibrinogen αC region promotes arterial thrombosis in the context of hypofibrinogenemia.Blood · 2026Article
- Suspected native aortic valve thrombosis complicated by recurrent left main coronary artery embolism and acquired Gerbode defect: a case report.European heart journal. Case reports · 2026Article
- High-throughput Image-based Matrix Analysis Platform Software: development of an algorithm for standardized characterization of high-resolution fibrin clot images.Research and practice in thrombosis and haemostasis · 2026Article
- Prothrombotic Tendency in the Shadow of Cancer: Hypercoagulability, Impaired Clot Contraction and Fibrinolysis in Colorectal Cancer and Gastric Cancer Patients Undergoing Chemotherapy.International journal of molecular sciences · 2026Article
- Experimental Characterisation of Differently Composed Thrombus Entities with Spectral-Detector-CT.Neurology international · 2026Article
- Multimodal characterization of flow-induced thrombus initiation and growth in extracorporeal membrane oxygenation.Scientific reports · 2026Article
- Enhancing diagnostic safety with low iodine, low radiation CTPA classification using deep learning.Scientific reports · 2026Article
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- Neutrophil extracellular traps formation is associated with impaired clot retraction and fibrinolysis in asthma.Frontiers in immunology · 2026Article
- Time-dependent effects of formalin fixation on magnetic resonance imaging relaxation times inAnnals of translational medicine · 2025Article
95 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
Although arterial and venous thromboembolic disorders are among the most frequent causes of mortality and morbidity, there has been little description of how the composition of thrombi and emboli depends on their vascular origin and age. We quantified the structure and composition of arterial and venous thrombi and pulmonary emboli using high-resolution scanning electron microscopy. Arterial thrombi contained a surprisingly large amount of fibrin, in addition to platelets. The composition of pulmonary emboli mirrored the most distal part of venous thrombi from which they originated, which differed from the structure of the body and head of the same thrombi. All thrombi and emboli contained few biconcave red blood cells but many polyhedrocytes or related forms of compressed red blood cells, demonstrating that these structures are a signature of clot contraction in vivo. Polyhedrocytes and intermediate forms comprised the major constituents of venous thrombi and pulmonary emboli. The structures within all of the thrombi and emboli were very tightly packed, in contrast to clots formed in vitro. There are distinctive, reproducible differences among arterial and venous thrombi and emboli related to their origin, destination and duration, which may have clinical implications for the understanding and treatment of thrombotic disorders.
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Registered trials
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