Evidence map›Paper›PMID 32198293›Full record

ArticlePediatrics2020

Perioperative Transfusions and Venous Thromboembolism.

Ruchika Goel, Cassandra D Josephson, Eshan U Patel, Molly R Petersen, Sarah Makhani, Steven M Frank, Paul M Ness, Evan M Bloch, Eric A Gehrie, Parvez M Lokhandwala and 5 more

Open access · bronzeAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
2.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.

  1. Research Priorities for Plasma and Platelet Transfusion Strategies in Critically Ill Children: From the Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2022
    Pooled it
  2. Pooled it
  3. Article
  4. Article
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  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 8 institutions in 1 country.

Ruchika GoelDivision of Transfusion Medicine, Department of Pathology, Johns Hopkins University, Baltimore, Maryland.
Cassandra D JosephsonDepartment of Pathology, School of Medicine, Emory University and cjoseph@emory.edu.
Eshan U PatelDivision of Transfusion Medicine, Department of Pathology, Johns Hopkins University, Baltimore, Maryland.
Molly R PetersenDivision of Transfusion Medicine, Department of Pathology, Johns Hopkins University, Baltimore, Maryland.
Sarah MakhaniHerbert Wertheim College of Medicine, Florida International University, Miami, Florida.
Steven M FrankDepartment of Anesthesiology, Johns Hopkins Hospital, Baltimore, Maryland.
Paul M NessDivision of Transfusion Medicine, Department of Pathology, Johns Hopkins University, Baltimore, Maryland.
Evan M BlochDivision of Transfusion Medicine, Department of Pathology, Johns Hopkins University, Baltimore, Maryland.
Eric A GehrieDivision of Transfusion Medicine, Department of Pathology, Johns Hopkins University, Baltimore, Maryland.
Parvez M LokhandwalaDivision of Transfusion Medicine, Department of Pathology, Johns Hopkins University, Baltimore, Maryland.
Marianne M NellisDepartment of Pediatrics, Weill Cornell Medicine, New York, New York.
Oliver KaramDepartment of Pediatrics, Children's Hospital of Richmond at Virginia Commonwealth University, Richmond, Virginia; and.
Beth H ShazNew York Blood Center, New York, New York.
Ravi M PatelDepartment of Pediatrics, Children's Healthcare of Atlanta and School of Medicine, Emory University, Atlanta, Georgia.
Aaron A R TobianDivision of Transfusion Medicine, Department of Pathology, Johns Hopkins University, Baltimore, Maryland.
Johns Hopkins University · USJohns Hopkins Medicine · USChildren's Healthcare of Atlanta · USCornell University · USFlorida International University · USJohns Hopkins Hospital · USNew York Blood Center · USVirginia Commonwealth University · US

Funding

THE RoLE OF NEONATAL ANEMIA IN LEARNING AND MEMORYP01HL046925 · NHLBI · UNIVERSITY OF IOWA · PI JOSEPHSON, CASSANDRA D · 1992 to 2022
$34.3M
Johns Hopkins HIV Epidemiology and Prevention Sciences Training ProgramT32AI102623 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Shruti H Mehta · 2013 to 2026
$5.3M
Unlocking the Potential of HIV-Infected Deceased Donors for Organ TransplantationR01AI120938 · NIAID · JOHNS HOPKINS UNIVERSITY · PI TOBIAN, AARON A · 2016 to 2021
$4.3M
Penile Microbiome, Inflammation and HIV Susceptibility During Sexual Debut and Maturation Among Male AdolescentsR01AI128779 · NIAID · JOHNS HOPKINS UNIVERSITY · PI TOBIAN, AARON A · 2017 to 2020
$2.1M
NHLBI NIH HHS P01 HL046925NIAID NIH HHS R01 AI120938NIAID NIH HHS R01 AI128779NIAID NIH HHS T32 AI102623
6 · The paper itself

Abstract

BACKGROUND AND

objectivesAnnual incidence of venous thromboembolism (VTE) including postoperative VTE in hospitalized children is rising significantly. A growing body of evidence supports the role of red blood cells (RBCs) in pathologic thrombosis. In this study, we examined the association of perioperative RBC transfusion with postoperative VTE in pediatric patients.

methodsThe pediatric databases of the American College of Surgeons' National Surgical Quality Improvement Project from 2012 to 2017 were used. Multivariable logistic regression was used to examine the association between perioperative RBC transfusion status and the development of new or progressive VTE within 30 days of surgery. The analyses were age stratified, as follows: neonates (≤28 days), infants (>28 days and <1 year), and children (≥1 year).

resultsIn this study, we included 20 492 neonates, 79 744 infants, and 382 862 children. Postoperative development of VTE was reported in 99 (0.48%) neonates, 147 (0.2%) infants, and 374 (0.1%) children. In all age groups, development of VTE was significantly more common among patients with a perioperative RBC transfusion than patients without a perioperative RBC transfusion (neonates: adjusted odds ratio [aOR] = 4.1, 95% confidence interval [CI] = 2.5-6.7; infants: aOR = 2.4, 95% CI = 1.7-3.6; children: aOR = 2.2, 95% CI = 1.7-2.9). Among children who received an intra- or postoperative transfusion, the weight-based volume of RBCs (mL/kg) transfused was associated with postoperative VTE in a dose-dependent manner: second tertile (odds ratio = 2.3, 95% CI = 1.3-4.1) and third tertile (odds ratio = 4.1, 95% CI = 2.3-7.4) versus first tertile.

conclusionsPerioperative RBC transfusions are independently associated with development of new or progressive postoperative VTE in children, infants, and neonates. These findings need further validation in prospective studies and emphasize the need for evidence-based perioperative pediatric blood transfusion decisions.

Indexed as

AdolescentChildChild, PreschoolConfidence IntervalsDatabases, FactualErythrocyte TransfusionHumansInfantInfant, NewbornOdds RatioPerioperative CareRegression AnalysisVenous Thromboembolism

Identifiers

PMID32198293
PMCPMC7111487
OpenAlexW3011262938

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.