ArticleProceedings of the National Academy of Sciences of the United States of America2020
Open access · bronzeAbstract read
In one paragraph
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.
0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed
1.6field-weighted citation impact, top 9% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
68 citing papers in PubMed, 99 citations in OpenAlex.
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- Balancing act of cytokines in controlling the severity ofInfection and immunity · 2026Review
- Uncovering an alternate pathway of antibiotic resistance in spore-forming bacteria.Nature communications · 2026Article
- Coupling Far-Western Blotting with Peptide Microarrays Reveals Novel E-Cadherin Spore-Surface Ligands inJournal of proteome research · 2026Article
- Association between postoperative Clostridioides difficile infection and outcomes following pancreatoduodenectomy for pancreatic cancer: a national cohort study.Surgical endoscopy · 2026Article
- Colonic epithelial regeneration shapes susceptibility tobioRxiv : the preprint server for biology · 2026Article
- Restoration of the Mucosal Barrier by Lactobacillus gasseri HDS0266 and Enterococcus faecium HDS0288 in Dextran Sodium Sulfate and Clostridioides difficile-Induced Colitis Mice.Probiotics and antimicrobial proteins · 2026Article
- Modeling Clostridioides difficile toxin pathogenesis and antiserum protection in an immunocompetent intestine-on-chip platform.Scientific reports · 2026Article
- Clostridioides difficile pathogenesis and control.Nature reviews. Microbiology · 2026Review
- A single amino acid substitution determines susceptibility ofFrontiers in cellular and infection microbiology · 2026Article
- Article
- CD44 is a macrophage receptor for TcdB fromGut microbes · 2025Article
- Mycotoxins and the Intestinal Epithelium: From Barrier Injury to Stem Cell Dysfunction.Toxins · 2025Review
- TMEM219 signaling promotes intestinal stem cell death and exacerbates colitis.The Journal of clinical investigation · 2025Article
- Therapeutic activation of IL-22-producing innate lymphoid cells enhances host defenses to Clostridioides difficile infection.Cell reports · 2025Article
- Article
- Mechanisms ofFrontiers in cellular and infection microbiology · 2025Review
- Harnessing 3D models to uncover the mechanisms driving infectious and inflammatory disease in the intestine.BMC biology · 2024Review
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 6 institutions in 2 countries.
Steven J MiletoInfection and Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.ORCID 0000-0003-2599-8957
Thierry JardéDevelopment and Stem Cells Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.ORCID 0000-0001-7483-8672
Kevin O ChildressDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232.ORCID 0000-0002-9082-5318
Jaime L JensenDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232.ORCID 0000-0002-8818-7513
Ashleigh P RogersInfection and Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.
Genevieve KerrDevelopment and Stem Cells Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.
Melanie L HuttonInfection and Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.ORCID 0000-0001-6470-2288
Michael J SheedloDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232.
Sarah C BlochDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232.
John A ShupeDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232.
Katja HorvayDevelopment and Stem Cells Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.
Tracey FloresDevelopment and Stem Cells Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.
Rebekah EngelDevelopment and Stem Cells Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.ORCID 0000-0003-1951-547X
Simon WilkinsCabrini Monash University Department of Surgery, Cabrini Hospital, Melbourne, VIC 3144, Australia.
Paul J McMurrickCabrini Monash University Department of Surgery, Cabrini Hospital, Melbourne, VIC 3144, Australia.
D Borden LacyDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232; borden.lacy@vanderbilt.edu helen.abud@monash.edu dena.lyras@monash.edu.ORCID 0000-0003-2273-8121
Helen E AbudDevelopment and Stem Cells Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia; borden.lacy@vanderbilt.edu helen.abud@monash.edu dena.lyras@monash.edu.
Dena LyrasInfection and Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia; borden.lacy@vanderbilt.edu helen.abud@monash.edu dena.lyras@monash.edu.ORCID 0000-0003-2345-9271
Vanderbilt University Medical Center · USAustralian Regenerative Medicine Institute · AUCabrini Hospital · AUMonash University · AUHudson Institute of Medical Research · AUVA Tennessee Valley Healthcare System · US
Funding
Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2002 to 2026
$29.9MTRAINING IN GASTROENTEROLOGYT32DK007673 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 1992 to 2026
$8.4MMOLECULAR BIOPHYSICS TRAINING PROGRAM AT VANDERBILTT32GM008320 · NIGMS · VANDERBILT UNIVERSITY · PI CHAZIN, WALTER J. · 1989 to 2023
$7.9MStructural mechanisms of Clostridium difficile pathogenesisR01AI095755 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI LACY, DANA BORDEN · 2011 to 2020
$3.9MStructural Mechanisms of Clostridioides difficile pathogenesisR37AI095755 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Dana Borden Lacy · 2021 to 2026
$3.2MNanoTemper Monolith NT.115 Microscale Thermophoresis (MST) instrumentS10OD021483 · OD · VANDERBILT UNIVERSITY · PI SPILLER, BENJAMIN W · 2016 to 2016
$136kThe role of toxins in Clostridium difficile infection pathogenesisI01BX002943 · VA · VETERANS HEALTH ADMINISTRATION · PI LACY, DANA BORDEN · 2016 to 2025
–BLRD VA I01 BX002943NIAID NIH HHS R01 AI095755NIAID NIH HHS R37 AI095755NIDDK NIH HHS P30 DK058404NIDDK NIH HHS T32 DK007673NIGMS NIH HHS T32 GM008320
Abstract
Gastrointestinal infections often induce epithelial damage that must be repaired for optimal gut function. While intestinal stem cells are critical for this regeneration process [R. C. van der Wath, B. S. Gardiner, A. W. Burgess, D. W. Smith,
Indexed as
AnimalsBacterial ProteinsBacterial ToxinsCells, CulturedClostridioides difficileClostridium InfectionsColonDisease Models, AnimalFemaleFrizzled ReceptorsHumansIntestinal MucosaMiceOrganoidsPrimary Cell CultureRecombinant ProteinsBacterial ProteinsBacterial ToxinsFrizzled ReceptorsRecombinant ProteinstoxB protein, Clostridium difficileClostridium difficilegut infectioninfectionstem cell damagetoxins
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.