SynthesisBrazilian journal of physical therapy
The addition of blood flow restriction to resistance exercise in individuals with knee pain: a systematic review and meta-analysis.
Synthesis in Brazilian journal of physical therapy. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 7 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 7 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Effects of blood-flow restriction training on dynamic postural control and ankle function in individuals with chronic ankle instability: a systematic review and meta-analysis of randomized controlled trials.Journal of orthopaedic surgery and research · 2026Pooled it
- Comparative effectiveness of exercise interventions for patellar tendinopathy: a systematic review and network meta-analysis of randomized controlled trials.BMC sports science, medicine & rehabilitation · 2026Pooled it
- Effects of blood flow restriction training on patients with chronic ankle instability: a systematic review and meta-analysis.BMC musculoskeletal disorders · 2025Pooled it
- Pooled it
- Preferred Reporting Items for Resistance Exercise Studies (PRIRES): A Checklist Developed Using an Umbrella Review of Systematic Reviews.Sports medicine - open · 2023Pooled it
- Benefits and Mechanisms of Exercise Training for Knee Osteoarthritis.Frontiers in physiology · 2021Pooled it
- Pooled it
- Rehabilitation efficacy of Low-Load blood flow restriction training for lateral patellar compression syndrome.Journal of orthopaedic surgery and research · 2026Trial
- Effects of Blood Flow Restriction Therapy in Individuals With Knee Osteoarthritis: Overview of Systematic Reviews.Clinical medicine insights. Arthritis and musculoskeletal disorders · 2026Review
- The effect of blood flow restricted exercise on measures of health and physical fitness across all populations: An umbrella review and meta-meta-analysis.Sports medicine and health science · 2025Review
- Article
- Trends and Practices on Blood Flow Restriction Training Are Not Largely Aligned With the Contemporary Evidence.Cureus · 2025Article
- Effects of Blood Flow Restriction Training on Strength and Functionality in People With Knee Arthropathies: A Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials.Translational sports medicine · 2025Review
- Effects of blood flow restriction therapy in patients with knee osteoarthritis: protocol for an overview of systematic reviews.Frontiers in rehabilitation sciences · 2024Review
- ADAPTations to low load blood flow restriction exercise versus conventional heavier load resistance exercise in UK military personnel with persistent knee pain: protocol for the ADAPT study, a multi-centre randomized controlled trial.BMC musculoskeletal disorders · 2023Article
- Low-Intensity Blood Flow Restriction Exercises Modulate Pain Sensitivity in Healthy Adults: A Systematic Review.Healthcare (Basel, Switzerland) · 2023Review
- Wrist Extensor Training With Blood Flow Restriction for the Management of Lateral Elbow Tendinopathy: A Case Report.Cureus · 2023Article
- Effect of Low-Load Blood Flow Restriction Training After Anterior Cruciate Ligament Reconstruction: A Systematic Review.International journal of sports physical therapy · 2022Article
- Comparison of Blood Flow Restriction Training versus Non-Occlusive Training in Patients with Anterior Cruciate Ligament Reconstruction or Knee Osteoarthritis: A Systematic Review.Journal of clinical medicine · 2020Review
- Reply to letter to the Editor about the article "The addition of blood flow restriction to resistance exercise in individuals with knee pain: a systematic review and meta-analysis".Brazilian journal of physical therapyArticle
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBlood flow restriction (BFR) is an effective clinical intervention used to increase strength in healthy individuals. However, its effects on pain and function in individuals with knee pain are unknown.
objectiveTo determine the effectiveness of adding BFR to resistance exercise for pain relief and improvement of function in patients with knee pain.
methodsSystematic review with meta-analysis of randomized clinical trials. Medline, Central, Embase, PEDro, Lilacs, CINAHL, SPORTDiscus, and Web of Science databases were searched from inception to May 2019. Randomized clinical trials that compared resistance exercise with or without BFR to treat knee pain and function in individuals older than 18 years of age with knee pain were included.
resultsEight randomized clinical trials met the eligibility criteria and for the quantitative synthesis, five studies were included. The pooled standardized mean difference (SMD) estimate showed that resistance exercises with BFR was not more effective than resistance exercises for reducing pain (SMD: -0.37cm, 95% CI=-0.93, 0.19) and improving knee function (SMD=-0.23 points, 95% CI=-0.71, 0.26) in patients with knee pain.
conclusionIn the short term, there is low quality of evidence that resistance exercise with BFR does not provide significant differences in pain relief and knee function compared to resistance exercises in patients with knee pain. PROSPERO registration number: CRD42018102839.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.