Evidence map›Paper›PMID 32197946›Full record

ReviewRedox biology2020

Sex differences in redox homeostasis in renal disease.

Tanecia Mitchell, Carmen De Miguel, Eman Y Gohar

Open access · goldAbstract readReview
In one paragraph

Review in Redox biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Salt Sensitivity of Blood Pressure in Women.Hypertension (Dallas, Tex. : 1979) · 2023
    Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. An investigation into the impact of deleting one copy of theRedox report : communications in free radical research · 2020
    Article
  16. Review
  17. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Tanecia MitchellDepartment of Urology, University of Alabama at Birmingham, Birmingham, AL, USA.
Carmen De MiguelSection of Cardio-Renal Physiology & Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Eman Y GoharSection of Cardio-Renal Physiology & Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address: emangohar@uabmc.edu.
University of Alabama at Birmingham · US

Funding

Monocyte Mitochondrial Dysfunction and Kidney Stone DiseaseK01DK106284 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MITCHELL, TANECIA R · 2016 to 2021
$912k
Role of endothelin in hypertension-mediated inflammation and end-organ damageK01HL145324 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DE MIGUEL, CARMEN · 2019 to 2023
$763k
Sex Differences in Renal Sodium HandlingK99DK119413 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GOHAR, EMAN · 2019 to 2020
$182k
NHLBI NIH HHS K01 HL145324NIDDK NIH HHS K01 DK106284NIDDK NIH HHS K99 DK119413
6 · The paper itself

Abstract

Sex differences in redox signaling in the kidney present new challenges and opportunities for understanding the physiology and pathophysiology of the kidney. This review will focus on reactive oxygen species, immune-related signaling pathways and endothelin-1 as potential mediators of sex-differences in redox homeostasis in the kidney. Additionally, this review will highlight male-female differences in redox signaling in several major cardiovascular and renal disorders namely acute kidney injury, diabetic nephropathy, kidney stone disease and salt-sensitive hypertension. Furthermore, we will discuss the contribution of redox signaling in the pathogenesis of postmenopausal hypertension and preeclampsia.

Indexed as

KidneySex CharacteristicsFemaleHomeostasisHumansMaleOxidation-ReductionPregnancyReactive Oxygen SpeciesReactive Oxygen SpeciesEndothelin-1InflammationKidneyRedox signalingROSSex-differences

Identifiers

PMID32197946
PMCPMC7212488
OpenAlexW3010665960

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.