ReviewPharmaceuticals (Basel, Switzerland)2020
Regenerative Injections Including 5% Dextrose and Platelet-Rich Plasma for the Treatment of Carpal Tunnel Syndrome: A Systematic Review and Network Meta-Analysis.
Review in Pharmaceuticals (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 31 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effectiveness in Functional Recovery and Pain Reduction Following Hydrodissection vs Rehabilitation in Patients With Carpal Tunnel Syndrome
Hyaluronic Acid Injection in Idiopathic Carpal Tunnel Syndrome; is it Effective as Local Corticosteroids? A Comparative Follow up Study
Who cites it
31 citing papers in PubMed, 3 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Ultrasound-Guided Nerve Hydrodissection for the Management of Carpal Tunnel Syndrome: A Systematic Review and Network Meta-Analysis.Yonsei medical journal · 2025Pooled it
- Injection therapy for carpal tunnel syndrome: A systematic review and network meta-analysis of randomized controlled trials.PloS one · 2024Pooled it
- Local injection therapy for carpal tunnel syndrome: a network meta-analysis of randomized controlled trial.Frontiers in pharmacology · 2023Pooled it
- Review
- A Brief Overview and Update of Regenerative Medicine for the Treatment of Musculoskeletal Conditions.Current reviews in musculoskeletal medicine · 2026Review
- Clinical application of ultrasound-guided acupotomy combined with platelet-rich plasma in the treatment of carpal tunnel syndrome.Frontiers in surgery · 2025Article
- Mechanisms for reducing/eliminating chronic neuropathic pain with a focus on platelet-rich plasma.Experimental biology and medicine (Maywood, N.J.) · 2025Review
- Subcutaneous injections of dextrose in musculoskeletal pain, a potential therapeutic intervention: scoping review.Pain management · 2024Article
- Dynamic Ultrasound Assessment and Guided Medial Plantar Nerve Hydrodissection for Master Knot of Henry Syndrome.Diagnostics (Basel, Switzerland) · 2024Article
- Article
- Treatment of posterior interosseous nerve entrapment syndrome with ultrasound-guided hydrodissection: A case report.World journal of clinical cases · 2023Article
- Ultrasound-guided median nerve hydrodissection of pronator teres syndrome: a case report and a literature review.Journal of ultrasonography · 2023Article
- Enhancing diagnosis and treatment of superior cluneal nerve entrapment: cadaveric, clinical, and ultrasonographic insights.Insights into imaging · 2023Article
- Ultrasound Imaging and Guidance for Distal Peripheral Nerve Pathologies at the Wrist/Hand.Diagnostics (Basel, Switzerland) · 2023Review
- Article
- Application of Repetitive Transcranial Magnetic Stimulation in Neuropathic Pain: A Narrative Review.Life (Basel, Switzerland) · 2023Review
- Article
- Platelet-rich plasma (PRP) in oncological patients: long-term oncological outcome analysis of the treatment of subcutaneous venous access device scars in 89 breast cancer patients.Archives of gynecology and obstetrics · 2022Article
- Intraovarian platelet-rich plasma administration could improve blastocyst euploidy rates in women undergoing in vitro fertilization.Clinical and experimental reproductive medicine · 2022Article
- The Effectiveness of Hydrodissection with 5% Dextrose for Persistent and Recurrent Carpal Tunnel Syndrome: A Retrospective Study.Journal of clinical medicine · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
This network meta-analysis aimed to integrate the available direct and indirect evidence on regenerative injections-including 5% dextrose (D5W) and platelet-rich plasma (PRP)-for the treatment of carpal tunnel syndrome (CTS). Literature reports comparing D5W and PRP injections with non-surgical managements of CTS were systematically reviewed. The main outcome was the standardized mean difference (SMD) of the symptom severity and functional status scales of the Boston Carpal Tunnel Syndrome Questionnaire at three months after injections. Ranking probabilities of the SMD of each treatment were acquired by using simulation. Ten studies with 497 patients and comparing five treatments (D5W, PRP, splinting, corticosteroid, and normal saline) were included. The results of the simulation of rank probabilities showed that D5W injection was likely to be the best treatment, followed by PRP injection, in terms of clinical effectiveness in providing symptom relief. With respect to functional improvement, splinting ranked higher than PRP and D5W injections. Lastly, corticosteroid and saline injections were consistently ranked fourth and fifth in terms of therapeutic effects on symptom severity and functional status. D5W and PRP injections are more effective than splinting and corticosteroid or saline injection for relieving the symptoms of CTS. Compared with splinting, D5W and PRP injections do not provide better functional recovery. More studies investigating the long-term effectiveness of regenerative injections in CTS are needed in the future.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.