Evidence map›Paper›PMID 32197509›Full record

ArticleBiomolecules2020

HO-1 Interactors Involved in the Colonization of the Bone Niche: Role of ANXA2 in Prostate Cancer Progression.

Nicolás Anselmino, Juan Bizzotto, Pablo Sanchis, Sofia Lage-Vickers, Emiliano Ortiz, Pia Valacco, Alejandra Paez, Estefania Labanca, Roberto Meiss, Nora Navone and 3 more

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Nicolás AnselminoUniversidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Departamento de Química Biológica, Laboratorio de Inflamación y Cáncer, Buenos Aires C1428EGA, Argentina.
Juan BizzottoUniversidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Departamento de Química Biológica, Laboratorio de Inflamación y Cáncer, Buenos Aires C1428EGA, Argentina.
Pablo SanchisUniversidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Departamento de Química Biológica, Laboratorio de Inflamación y Cáncer, Buenos Aires C1428EGA, Argentina.
Sofia Lage-VickersUniversidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Departamento de Química Biológica, Laboratorio de Inflamación y Cáncer, Buenos Aires C1428EGA, Argentina.
Emiliano OrtizUniversidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Departamento de Química Biológica, Laboratorio de Inflamación y Cáncer, Buenos Aires C1428EGA, Argentina.
Pia ValaccoUniversidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Departamento de Química Biológica, Laboratorio de Inflamación y Cáncer, Buenos Aires C1428EGA, Argentina.
Alejandra PaezUnidad de Transferencia Genética, Instituto de Oncología "Angel H Roffo", Universidad de Buenos Aires, Buenos Aires C1417DTB, Argentina.
Estefania LabancaDepartment of Genitourinary Medical Oncology and the David H. Koch Center for Applied Research of Genitourinary Cancers, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Roberto MeissAcademia Nacional de Medicina, Buenos Aires C1425ASU, Argentina.
Nora NavoneDepartment of Genitourinary Medical Oncology and the David H. Koch Center for Applied Research of Genitourinary Cancers, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Javier CotignolaUniversidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Departamento de Química Biológica, Laboratorio de Inflamación y Cáncer, Buenos Aires C1428EGA, Argentina.
Elba VazquezUniversidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Departamento de Química Biológica, Laboratorio de Inflamación y Cáncer, Buenos Aires C1428EGA, Argentina.
Geraldine GueronUniversidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Departamento de Química Biológica, Laboratorio de Inflamación y Cáncer, Buenos Aires C1428EGA, Argentina.
Consejo Nacional de Investigaciones Científicas y Técnicas · ARThe University of Texas MD Anderson Cancer Center · USAcademia Nacional de Medicina · ARUniversidad de Buenos Aires · AR

Funding

Targeting Tumor Microenvironment-Induced Therapy Resistance in Prostate Cancer Bone MetastasisP50CA140388 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI THOMPSON, TIMOTHY CHARLES · 2009 to 2022
$23.4M
AGENCIA-PICT RAICES 2018-02639AGENCIA-PICT UBACyT 2015-1786AGENCIA-PICT UBACyT 2016-1366NCI NIH HHS P50 CA140388
6 · The paper itself

Abstract

backgroundProstate cancer (PCa) dissemination shows a tendency to develop in the bone, where heme oxygenase 1 (HO-1) plays a critical role in bone remodeling. Previously by LC/ESI-MSMS, we screened for HO-1 interacting proteins and identified annexin 2 (ANXA2). The aim of this study was to analyze the relevance of ANXA2/HO-1 in PCa and bone metastasis.

methodsWe assessed

resultsUnder co-culture conditions,

conclusionsANXA2/HO-1 rises as a critical axis in PCa.

Indexed as

Tumor MicroenvironmentAnimalsAnnexin A2Bone and BonesBone NeoplasmsHeme Oxygenase-1HumansMaleMiceNeoplasm MetastasisNeoplasm ProteinsPC-3 CellsProstatic NeoplasmsRAW 264.7 CellsAnnexin A2ANXA2 protein, humanHeme Oxygenase-1HMOX1 protein, humanNeoplasm Proteinsheme-oxygenase-1 (HO-1), prostate cancer (PCa), annexin A2 (ANXA2), bonemetastasisurokinase-plasminogen activator (uPA)

Identifiers

PMID32197509
PMCPMC7175266
OpenAlexW3011260792

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.