ArticleJournal of clinical medicine2020
Network Mapping of Connectivity Alterations in Disorder of Consciousness: Towards Targeted Neuromodulation.
Article in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- Early High-Frequency Network Reorganization After Spinal Cord Stimulation Is Linked to Long-Term Recovery in Disorders of Consciousness.CNS neuroscience & therapeutics · 2026Article
- Effects of Multi-Sensory Stimulation on Brain Functional Connectivity in Patients with Disorders of Consciousness.Brain sciences · 2026Article
- Exploration of resting-state brain functional connectivity as preclinical markers for arousal prediction in prolonged disorders of consciousness: A pilot study based on functional near-infrared spectroscopy.Brain and behavior · 2024Article
- Article
- Disorder of consciousness: Structural integrity of brain networks for the clinical assessment.Annals of clinical and translational neurology · 2023Article
- Disrupted multi-scale topological organization of directed functional brain networks in patients with disorders of consciousness.Brain communications · 2023Article
- Brain Metabolic Connectivity Patterns in Patients with Prolonged Disorder of Consciousness after Hypoxic-Ischemic Injury: A Preliminary Study.Brain sciences · 2022Article
- Modulation of cerebral cortex activity by acupuncture in patients with prolonged disorder of consciousness: An fNIRS study.Frontiers in neuroscience · 2022Article
- Metabolic connectivity of resting-state networks in alpha synucleinopathies, from prodromal to dementia phase.Frontiers in neuroscience · 2022Article
- Positive effects of music therapist's selected auditory stimulation on the autonomic nervous system of patients with disorder of consciousness: a randomized controlled trial.Neural regeneration research · 2021Article
- Tumor BOLD connectivity profile correlates with glioma patients' survival.Neuro-oncology advancesArticle
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Authors and funding
7 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Disorder of consciousness (DoC) refers to a group of clinical conditions that may emerge after brain injury, characterized by a varying decrease in the level of consciousness that can last from days to years. An understanding of its neural correlates is crucial for the conceptualization and application of effective therapeutic interventions. Here we propose a quantitative meta-analysis of the neural substrate of DoC emerging from functional magnetic resonance (fMRI) and positron emission tomography (PET) studies. We also map the relevant networks of resulting areas to highlight similarities with Resting State Networks (RSNs) and hypothesize potential therapeutic solutions leveraging network-targeted noninvasive brain stimulation. Available literature was reviewed and analyzed through the activation likelihood estimate (ALE) statistical framework to describe resting-state or task-dependent brain activation patterns in DoC patients. Results show that task-related activity is limited to temporal regions resembling the auditory cortex, whereas resting-state fMRI data reveal a diffuse decreased activation affecting two subgroups of cortical (angular gyrus, middle frontal gyrus) and subcortical (thalamus, cingulate cortex, caudate nucleus) regions. Clustering of their cortical functional connectivity projections identify two main altered functional networks, related to decreased activity of (i) the default mode and frontoparietal networks, as well as (ii) the anterior salience and visual/auditory networks. Based on the strength and topography of their connectivity profile, biophysical modeling of potential brain stimulation solutions suggests the first network as the most feasible target for tES, tDCS neuromodulation in DoC patients.
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