Evidence map›Paper›PMID 32197382›Full record

ReviewCells2020

Revisiting the Interaction of γδ T-Cells and B-Cells.

Francesca Rampoldi, Leon Ullrich, Immo Prinz

Open access · goldAbstract readReview
In one paragraph

Review in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 57 citations in OpenAlex.

  1. Review
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  13. γδ T cells in immune-mediated kidney disease.European journal of immunology · 2024
    Review
  14. Review
  15. Review
  16. Cytomegalovirus drives Vδ1Nature communications · 2024
    Article
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Francesca RampoldiInstitute of Immunology, Hannover Medical School, 30625 Hannover, Germany.
Leon UllrichInstitute of Immunology, Hannover Medical School, 30625 Hannover, Germany.
Immo PrinzInstitute of Immunology, Hannover Medical School, 30625 Hannover, Germany.ORCID 0000-0002-8789-9578
Medizinische Hochschule Hannover · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Right after the discovery of γδ T-cells in 1984, people started asking how γδ T-cells interact with other immune cells such as B-cells. Early reports showed that γδ T-cells are able to help B-cells to produce antibodies and to sustain the production of germinal centers. Interestingly, the presence of γδ T-cells seems to promote the generation of antibodies against "self" and less against challenging pathogens. More recently, these hypotheses were supported using γδ T-cell-deficient mouse strains, in different mouse models of systemic lupus erythematous, and after induction of epithelial cell damage. Together, these studies suggest that the link between γδ T-cells and the production of autoantibodies may be more relevant for the development of autoimmune diseases than generally acknowledged and thus targeting γδ T-cells could represent a new therapeutic strategy. In this review, we focus on what is known about the communication between γδ T-cells and B-cells, and we discuss the importance of this interaction in the context of autoimmunity.

Indexed as

Cell CommunicationAnimalsAutoimmune DiseasesB-LymphocytesGerminal CenterHumansReceptors, Antigen, T-Cell, gamma-deltaT-LymphocytesReceptors, Antigen, T-Cell, gamma-deltaautoantibodiesB-cellsIL-4γδ T–B-cell interactionγδ T-cells

Identifiers

PMID32197382
PMCPMC7140609
OpenAlexW3012531269

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.