ArticleBiophysical journal2020
Fundamental Characteristics of Neuron Adhesion Revealed by Forced Peeling and Time-Dependent Healing.
Article in Biophysical journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Method for AFM investigation of lateral forces required for the surface detachment of neurites.Scientific reports · 2026Article
- Biocompatible EDOT-Pyrrole Conjugated Conductive Polymer Coating for Augmenting Cell Attachment, Activity, and Differentiation.ACS applied bio materials · 2025Article
- A mechanism-based theory of cellular and tissue plasticity.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Active chemo-mechanical feedbacks dictate the collective migration of cells on patterned surfaces.Biophysical journal · 2022Article
- Neuromechanobiology: An Expanding Field Driven by the Force of Greater Focus.Advanced healthcare materials · 2021Review
- Effect of Cyclic Stretch on Neuron Reorientation and Axon Outgrowth.Frontiers in bioengineering and biotechnology · 2020Article
- Maturation of Neural Cells Leads to Enhanced Axon-Extracellular Matrix Adhesion and Altered Injury Response.Frontiers in bioengineering and biotechnology · 2020Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A current bottleneck in the advance of neurophysics is the lack of reliable methods to quantitatively measure the interactions between neural cells and their microenvironment. Here, we present an experimental technique to probe the fundamental characteristics of neuron adhesion through repeated peeling of well-developed neurite branches on a substrate with an atomic force microscopy cantilever. At the same time, a total internal reflection fluorescence microscope is also used to monitor the activities of neural cell adhesion molecules (NCAMs) during detaching. It was found that NCAMs aggregate into clusters at the neurite-substrate interface, resulting in strong local attachment with an adhesion energy of ∼0.1 mJ/m
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Registered trials
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