Evidence map›Paper›PMID 32197047›Full record

Observational studyAmerican journal of respiratory and critical care medicine2020

Clarifying the Risk of Lung Disease in SZ Alpha-1 Antitrypsin Deficiency.

Alessandro N Franciosi, Brian D Hobbs, Oliver J McElvaney, Kevin Molloy, Craig Hersh, Louise Clarke, Cedric Gunaratnam, Edwin K Silverman, Tomás P Carroll, Noel G McElvaney

Open access · greenAbstract readObservational Study
In one paragraph

Observational study in American journal of respiratory and critical care medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.

  1. Disease burden associated with alpha-1 antitrypsin deficiency: systematic and structured literature reviews.European respiratory review : an official journal of the European Respiratory Society · 2022
    Pooled it
  2. Review
  3. Review
  4. Article
  5. Alpha-1 Antitrypsin Levels and Phenotypes in Patients with Asthma and COPD in Appalachian East Tennessee.International journal of chronic obstructive pulmonary disease · 2026
    Article
  6. Article
  7. Mendelian causes of early-onset emphysema: a review of the current literature.European respiratory review : an official journal of the European Respiratory Society · 2025
    Review
  8. Review
  9. Observational
  10. Article
  11. Article
  12. Review
  13. Recommendations for the diagnosis and treatment of alpha-1 antitrypsin deficiency.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2024
    Article
  14. Undiagnosed Alpha-1 Antitrypsin Deficiency and the Perpetuation of Lung Health Inequity.American journal of respiratory and critical care medicine · 2024
    Article
  15. Testing Alpha-1 Antitrypsin Deficiency in Black Populations.Advances in respiratory medicine · 2023
    Review
  16. Observational
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Alessandro N FranciosiIrish Centre for Genetic Lung Disease and.ORCID 0000-0002-4241-8718
Brian D HobbsChanning Division of Network Medicine and.ORCID 0000-0001-9564-0745
Oliver J McElvaneyIrish Centre for Genetic Lung Disease and.
Kevin MolloyIrish Centre for Genetic Lung Disease and.
Craig HershChanning Division of Network Medicine and.ORCID 0000-0002-1342-4334
Louise ClarkeDepartment of Pulmonary Physiology, Beaumont Hospital, Dublin, Ireland; and.
Cedric GunaratnamIrish Centre for Genetic Lung Disease and.
Edwin K SilvermanChanning Division of Network Medicine and.
Tomás P CarrollIrish Centre for Genetic Lung Disease and.ORCID 0000-0002-0418-1641
Noel G McElvaneyIrish Centre for Genetic Lung Disease and.
Brigham and Women's Hospital · USBeaumont Hospital · IERoyal College of Surgeons in Ireland · IE

Funding

Multi-omic Subtyping of Chronic Obstructive Pulmonary DiseaseK08HL136928 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI HOBBS, BRIAN DANIEL · 2017 to 2021
$864k
NHLBI NIH HHS K08 HL136928
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Smoking CessationAdultAgedAged, 80 and overalpha 1-Antitrypsin DeficiencyCase-Control StudiesFemaleGenotypeHumansLinear ModelsLongitudinal StudiesMaleMiddle AgedPhenotypeProspective StudiesPulmonary Disease, Chronic Obstructivechronic obstructive pulmonary diseasegenotypephenotypePiSZ

Identifiers

PMID32197047
PMCPMC7530947
OpenAlexW3011439947

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.