ArticleThoracic cancer2020
Malignant solitary fibrous tumor occurring in the mediastinal pleura showing NAB2ex4-STAT6ex2 fusion and negative STAT6 immunohistochemistry: A case report.
Article in Thoracic cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
- Hybrid video-assisted thoracoscopic resection of a massive mediastinal solitary fibrous tumor: overcoming challenges: a case report.Journal of medical case reports · 2025Article
- Solitary Fibrous Tumor of the Pleura: A Clinical Case of a Giant Malignant Tumor With Post-surgical Recurrence.Cureus · 2025Article
- Malignant solitary fibrous tumor in the central nervous system treated with surgery, radiotherapy and anlotinib: A case report.World journal of clinical cases · 2022Article
- Clinical Features, Management, and Prognostic Factors of Intracranial Solitary Fibrous Tumor.Frontiers in oncology · 2022Article
- Case Report: Molecular Characterization of Aggressive Malignant Retroperitoneal Solitary Fibrous Tumor: A Case Study.Frontiers in oncology · 2021Article
- Pelvic cavity malignant solitary fibrous tumor with dedifferentiation and multifocal cytokeratin expression.International journal of clinical and experimental pathology · 2021Article
- Rapidly growing solitary fibrous tumors of the pleura: a case report and review of the literature.Annals of translational medicine · 2020Article
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9 authors at 1 institution in 1 country.
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Abstract
Solitary fibrous tumor (SFT) is a rare clinical tumor, defined as a mesenchymal tumor of fibroblastic origin. A classic SFT is benign in most cases, but its clinical behavior is unpredictable. Lately, molecular analyses has discovered that almost all SFTs harbor an NAB2-STAT6 fusion gene, which is considered specific to this tumor type. Recent studies have suggested that nuclear STAT6 immunoreactivity is a highly sensitive and specific marker of SFTs and can be helpful when diagnosis is inconclusive by conventional methods. We herein report the case of a rare malignant solitary fibrous tumor occurring in the mediastinal pleura. An 82-year-old Chinese man with intermittent breathlessness was referred to our hospital. Chest CT showed a significantly enhanced irregular huge soft tissue mass in the anterior mediastinal area. After radical resection, the immunohistochemistry staining results of the sample showed that STAT6 was negative. The final diagnosis was confirmed by qualitative endpoint reverse transcriptase-polymerase chain reaction technique, showing positive NAB2ex4-STAT6ex2 fusion.
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