ArticleChembiochem : a European journal of chemical biology2020
New Nocobactin Derivatives with Antimuscarinic Activity, Terpenibactins A-C, Revealed by Genome Mining of Nocardia terpenica IFM 0406.
Article in Chembiochem : a European journal of chemical biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed.
- Genome Mining Leads to the Discovery of Kasichelins A-D, Unusual β-Alanine- and β-Aminoisobutyric Acid-Containing Siderophores fromJournal of natural products · 2025Article
- Multiple regulators control the biosynthesis of brasilicardin in Nocardia terpenica.Applied microbiology and biotechnology · 2025Article
- Strategies for Actinobacteria Isolation, Cultivation, and Metabolite Production that Are Biologically Important.ACS omega · 2025Review
- Search for natural products from actinomycetes of the genus Nocardia.Journal of natural medicines · 2024Review
- Discovery and Characterization of the Fully Decorated Nocardiosis-Associated Polyketide Natural Product.Journal of the American Chemical Society · 2024Article
- Nobachelins, new siderophores fromSynthetic and systems biotechnology · 2023Article
- Bioinformatics-guided discovery of biaryl-linked lasso peptides.Chemical science · 2023Article
- Bioinformatics-Guided Discovery of Biaryl-Tailored Lasso Peptides.bioRxiv : the preprint server for biology · 2023Article
- Synergetic Antimicrobial Activity and Mechanism of Clotrimazole-Linked CO-Releasing Molecules.ACS bio & med chem Au · 2022Article
- Amamistatins isolated fromBeilstein journal of organic chemistry · 2022Article
- Nocathioamides, Uncovered by a Tunable Metabologenomic Approach, Define a Novel Class of Chimeric Lanthipeptides.Angewandte Chemie (International ed. in English) · 2021Article
- Insights from the comparative genome analysis of natural rubber degradingBioinformation · 2021Article
- ImprovedMicrobiology resource announcements · 2020Article
- New Nocobactin Derivatives with Antimuscarinic Activity, Terpenibactins A-C, Revealed by Genome Mining of Nocardia terpenica IFM 0406.Chembiochem : a European journal of chemical biology · 2020Article
- Comparative Genomics and Metabolomics in the GenusmSystems · 2020Article
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8 authors.
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Abstract
We report a genomics-guided exploration of the metabolic potential of the brasilicardin producer strain Nocardia terpenica IFM 0406. Bioinformatics analysis of the whole genome sequence revealed the presence of a biosynthetic gene cluster presumably responsible for the generation of formerly unknown nocobactin derivatives. Mass spectrometry-assisted isolation led to the identification of three new siderophores, terpenibactins A (1), B (2) and C (3), which belong to the class of nocobactins. Their structures were elucidated by employing spectroscopic techniques. Compounds 1-3 demonstrated inhibitory activity towards the muscarinic M3 receptor, while exhibiting only a low cytotoxicity.
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