ArticleAngewandte Chemie (International ed. in English)2020
Catalytic Behavior of Mono-N-Protected Amino-Acid Ligands in Ligand-Accelerated C-H Activation by Palladium(II).
Article in Angewandte Chemie (International ed. in English), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Article
- Divergent Kinetic/Thermodynamic Selectivity in Palladium(II)-Mediated C-H Activation to Form 5- and 6-Membered Palladacycles.Journal of the American Chemical Society · 2025Article
- Selective C-H Activation of Unprotected Allylamines by Control of Catalyst Speciation.Chem catalysis · 2023Article
- Palladium mono-Chemical science · 2023Article
- Charge-controlled Pd catalysis enables theChem · 2023Article
- Dual ligand approach increases functional group tolerance in the Pd-catalysed C-H arylation ofChemical science · 2023Article
- Pd-catalysed C-H functionalisation of free carboxylic acids.Chemical science · 2022Review
- Transition-Metal-Catalyzed Annulations Involving the Activation of C(spAngewandte Chemie (International ed. in English) · 2022Review
- Tailored quinones support high-turnover Pd catalysts for oxidative C-H arylation with OScience (New York, N.Y.) · 2020Article
- Sterically Controlled C-H Olefination of Heteroarenes.Angewandte Chemie (International ed. in English) · 2020Article
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6 authors.
Funding
Abstract
Mono-N-protected amino acids (MPAAs) are increasingly common ligands in Pd-catalyzed C-H functionalization reactions. Previous studies have shown how these ligands accelerate catalytic turnover by facilitating the C-H activation step. Here, it is shown that MPAA ligands exhibit a second property commonly associated with ligand-accelerated catalysis: the ability to support catalytic turnover at substoichiometric ligand-to-metal ratios. This catalytic role of the MPAA ligand is characterized in stoichiometric C-H activation and catalytic C-H functionalization reactions. Palladacycle formation with substrates bearing carboxylate and pyridine directing groups exhibit a 50-100-fold increase in rate when only 0.05 equivalents of MPAA are present relative to Pd
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