ArticlePLoS biology2020
Drosophila-associated bacteria differentially shape the nutritional requirements of their host during juvenile growth.
Article in PLoS biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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Who cites it
58 citing papers in PubMed, 123 citations in OpenAlex.
- Trial
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- A nutrient-sensitive enterokine coordinates developmental plasticity through inter-organ signaling.PLoS biology · 2026Article
- Review
- Short lifespan under dietary cholesterol depletion is associated with gut dysfunction in Drosophila melanogaster females.npj aging · 2026Article
- The Lolal-dpp axis mediates the regulation of host reproduction by gut symbionts in insects.Nature communications · 2026Article
- Phylosymbiosis and functional redundancy in the Drosophila (Diptera: Drosophilidae) gut microbiome and its implications for host fitness.Journal of insect science (Online) · 2026Article
- Dietary Lipids and Their Metabolism in the Midgut.Advances in experimental medicine and biology · 2026Review
- The Gut Microbiota ofMicroorganisms · 2025Review
- Is it time to assignApplied and environmental microbiology · 2025Article
- Gut microbiome and host TOR pathway interact to regulate predator-induced aversive memory inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Variation in diet concentration and bacterial inoculum size in larval habitats shapes the performance of the Asian tiger mosquito, Aedes albopictus.Microbiome · 2025Article
- Dietary Zinc Limitation Dictates Lifespan and Reproduction Trade-Offs of Drosophila Mothers.Aging cell · 2025Article
- ArtSymbioCyc, a metabolic network database collection dedicated to arthropod symbioses: a case study, the tripartite cooperation inmSystems · 2025Article
- Different Long-Term Nutritional Regimens ofInsects · 2025Article
- The integral role of the Black Soldier fly,Frontiers in microbiomes · 2025Review
- Intestinal commensal bacteria promote Bactrocera dorsalis larval development through the vitamin B6 synthesis pathway.Microbiome · 2024Article
- Feeding Drosophila gut microbiomes from young and old flies modifies the microbiome.Scientific reports · 2024Article
- High-fat diets induce inflammatory IMD/NFκB signaling via gut microbiota remodeling inFrontiers in cellular and infection microbiology · 2024Article
- Identification of key yeast species and microbe-microbe interactions impacting larval growth ofeLife · 2023Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The interplay between nutrition and the microbial communities colonizing the gastrointestinal tract (i.e., gut microbiota) determines juvenile growth trajectory. Nutritional deficiencies trigger developmental delays, and an immature gut microbiota is a hallmark of pathologies related to childhood undernutrition. However, how host-associated bacteria modulate the impact of nutrition on juvenile growth remains elusive. Here, using gnotobiotic Drosophila melanogaster larvae independently associated with Acetobacter pomorumWJL (ApWJL) and Lactobacillus plantarumNC8 (LpNC8), 2 model Drosophila-associated bacteria, we performed a large-scale, systematic nutritional screen based on larval growth in 40 different and precisely controlled nutritional environments. We combined these results with genome-based metabolic network reconstruction to define the biosynthetic capacities of Drosophila germ-free (GF) larvae and its 2 bacterial partners. We first established that ApWJL and LpNC8 differentially fulfill the nutritional requirements of the ex-GF larvae and parsed such difference down to individual amino acids, vitamins, other micronutrients, and trace metals. We found that Drosophila-associated bacteria not only fortify the host's diet with essential nutrients but, in specific instances, functionally compensate for host auxotrophies by either providing a metabolic intermediate or nutrient derivative to the host or by uptaking, concentrating, and delivering contaminant traces of micronutrients. Our systematic work reveals that beyond the molecular dialogue engaged between the host and its bacterial partners, Drosophila and its associated bacteria establish an integrated nutritional network relying on nutrient provision and utilization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.