Evidence map›Paper›PMID 32196360›Full record

Trial reportAmerican journal of physiology. Heart and circulatory physiology2020

Tobacco and electronic cigarettes adversely impact ECG indexes of ventricular repolarization: implication for sudden death risk.

Michelle Ip, Evangelos Diamantakos, Kacey Haptonstall, Yasmine Choroomi, Roya S Moheimani, Kevin Huan Nguyen, Elizabeth Tran, Jeffrey Gornbein, Holly R Middlekauff

Open access · greenAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in American journal of physiology. Heart and circulatory physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 2 pooled it
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 62 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  5. Article
  6. Article
  7. Article
  8. Influence of e-cigarettes and their constituents on cardiac rhythm and arrhythmias.American journal of physiology. Heart and circulatory physiology · 2026
    Review
  9. Review
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  11. Review
  12. Article
  13. Article
  14. Review
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  17. Article
  18. Nicotine Formulation Influences the Autonomic and Arrhythmogenic Effects of Electronic Cigarettes.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2024
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Michelle IpDivision of Cardiology, Department of Medicine, David Geffen School of Medicine at the University of California, Los Angeles, California.
Evangelos DiamantakosDivision of Cardiology, Department of Medicine, David Geffen School of Medicine at the University of California, Los Angeles, California.
Kacey HaptonstallDivision of Cardiology, Department of Medicine, David Geffen School of Medicine at the University of California, Los Angeles, California.
Yasmine ChoroomiDivision of Cardiology, Department of Medicine, David Geffen School of Medicine at the University of California, Los Angeles, California.
Roya S MoheimaniDivision of Cardiology, Department of Medicine, David Geffen School of Medicine at the University of California, Los Angeles, California.
Kevin Huan NguyenDivision of Cardiology, Department of Medicine, David Geffen School of Medicine at the University of California, Los Angeles, California.ORCID 0000-0002-8327-268X
Elizabeth TranDivision of Cardiology, Department of Medicine, David Geffen School of Medicine at the University of California, Los Angeles, California.
Jeffrey GornbeinDepartments of Medicine and Computational Medicine, David Geffen School of Medicine at the University of California, Los Angeles, California.
Holly R MiddlekauffDivision of Cardiology, Department of Medicine, David Geffen School of Medicine at the University of California, Los Angeles, California.
University of California, Los Angeles · US

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
NCATS NIH HHS UL1 TR001881
6 · The paper itself

Abstract

Tobacco cigarette smoking is associated with increased sudden death risk, perhaps through adverse effects on ventricular repolarization. The effect of electronic (e-)cigarettes on ventricular repolarization is unknown. The objective of the study was to test the hypothesis that tobacco cigarettes and e-cigarettes have similar adverse effects on electrocardiogram (ECG) indexes of ventricular repolarization and these effects are attributable to nicotine. ECG recordings were obtained in 37 chronic tobacco cigarette smokers, 43 chronic e-cigarette users, and 65 nonusers. Primary outcomes, Tpeak to Tend (Tp-e), Tp-e/QT ratio, and Tp-e/QTc ratio, were measured in tobacco cigarette smokers pre-/post-straw control and smoking one tobacco cigarette and in e-cigarette users and nonusers pre-/post-straw control and using an e-cigarette with and without nicotine (different days). Mean values of the primary outcomes were not different among the three groups at baseline. In chronic tobacco cigarette smokers, all primary outcomes, including the Tp-e (12.9 ± 5.0% vs. 1.5 ± 5%,

Indexed as

Action PotentialsAdultDeath, Sudden, CardiacFemaleHeart RateHumansMaleNicotineNicotinic AgonistsTobacco SmokingVapingVentricular FunctionNicotineNicotinic Agonistselectronic cigarettesnicotinesmokingsudden deathtobacco cigarettesventricular repolarization

Identifiers

PMID32196360
PMCPMC7346537
OpenAlexW3012541589

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.