ArticleInvestigative ophthalmology & visual science2020
Assessing Ganglion Cell Layer Topography in Human Albinism Using Optical Coherence Tomography.
Article in Investigative ophthalmology & visual science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 17 citations in OpenAlex.
- The Human Fovea Is Relatively Horizontally Elongated in Infantile Nystagmus.Investigative ophthalmology & visual science · 2025Article
- Quantitative Foveal Structural Metrics as Predictors of Visual Acuity in Human Albinism.Investigative ophthalmology & visual science · 2024Article
- Temporal-to-Nasal Macular Ganglion Cell and Inner Plexiform Layer Ratios in a Large Adult Twin Cohort: Correlations With Age and Heritability.Investigative ophthalmology & visual science · 2024Article
- Visual Field Deficits in Albinism in Comparison to Idiopathic Infantile Nystagmus.Investigative ophthalmology & visual science · 2024Article
- Phenotypic Features Determining Visual Acuity in Albinism and the Role of Amblyogenic Factors.Investigative ophthalmology & visual science · 2024Article
- Clinical features and imaging characteristics in achiasmia.Brain communications · 2023Article
- Optical Coherence Tomography as a Biomarker for Differential Diagnostics in Nystagmus: Ganglion Cell Layer Thickness Ratio.Journal of clinical medicine · 2022Article
- Retinal alterations in patients with Lafora disease.American journal of ophthalmology case reports · 2021Article
- Promises and pitfalls of evaluating photoreceptor-based retinal disease with adaptive optics scanning light ophthalmoscopy (AOSLO).Progress in retinal and eye research · 2021Review
- Examining Whether AOSLO-Based Foveal Cone Metrics in Achromatopsia and Albinism Are Representative of Foveal Cone Structure.Translational vision science & technology · 2021Article
- Article
- Characterization of Retinal Thickness in Individuals with Albinism: Baseline Data for a Black South African Population.Clinical optometry · 2021Article
- The Influence of Axial Length Upon the Retinal Ganglion Cell Layer of the Human Eye.Translational vision science & technology · 2020Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
Purpose: To test whether ganglion cell layer (GCL) and inner plexiform layer (IPL) topography is altered in albinism. Methods: Optical coherence tomography scans were analyzed in 30 participants with albinism and 25 control participants. Horizontal and vertical line scans were acquired at the fovea, then strip registered and averaged. The Duke Optical Coherence Tomography Retinal Analysis Program was used to automatically segment the combined GCL and IPL and total retinal thickness, followed by program-assisted manual segmentation of the boundary between the GCL and IPL. Layer thickness and area under the curve (AUC) were calculated within 2.5 mm of the fovea. Nasal-temporal and superior-inferior asymmetry were calculated as an AUC ratio in each quadrant. Results: GCL and IPL topography varied between participants. The summed AUC in all quadrants was similar between groups for both the GCL (P = 0.84) and IPL (P = 0.08). Both groups showed nasal-temporal asymmetry in the GCL, but only participants with albinism had nasal-temporal asymmetry in the IPL. Nasal-temporal asymmetry was greater in albinism for both the GCL (P < 0.0001) and the IPL (P = 0.0006). The GCL usually comprised a greater percentage of the combined GCL and IPL in controls than in albinism. Conclusions: The GCL and IPL have greater structural variability than previously reported. GCL and IPL topography are significantly altered in albinism, which suggests differences in the spatial distribution of retinal ganglion cells. This finding provides insight into foveal development and structure-function relationships in foveal hypoplasia.
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