Evidence map›Paper›PMID 32195815›Full record

ArticleJournal of hypertension2020

Heritability and genetic correlations of obesity indices with ambulatory and office beat-to-beat blood pressure in the Oman Family Study.

Tengfei Man, Ilja M Nolte, Deepali Jaju, Zahir A M Al-Anqoudi, M Loretto Muñoz, Mohammed O Hassan, Said Al-Yahyaee, Riad A Bayoumi, Anthony G Comuzzie, John S Floras and 4 more

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In one paragraph

Article in Journal of hypertension, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Tengfei ManDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, The Netherlands.
Ilja M NolteDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, The Netherlands.
Deepali JajuCollege of Medicine and Health Sciences, Sultan Qaboos University, Muscat.
Zahir A M Al-AnqoudiOman Family Study Research Centre, Directorate General of Health Services, Adakhlya Governorate, Nizwa.
M Loretto MuñozDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, The Netherlands.
Mohammed O HassanCanadian Health Centre, Muscat.
Said Al-YahyaeeDepartment of Biochemistry, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Sultanate of Oman.
Riad A BayoumiCollege of Medicine, Mohammed Bin Rashid University for Medicine and Health Science, Dubai, UAE.
Anthony G ComuzzieDepartment of Genetics, Texas Biomedical Research Institute, San Antonio, Texas, USA.
John S FlorasUniversity Health Network and Mount Sinai Hospital Division of Cardiology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
Arie M van RoonDepartment of Vascular Medicine, University of Groningen, University Medical Center Groningen, The Netherlands.
Harriëtte RieseInterdisciplinary Center Psychopathology and Emotion regulation, Department of Psychiatry, University of Groningen, University Medical Center Groningen, The Netherlands.
Sulayma AlbarwaniCollege of Medicine and Health Sciences, Sultan Qaboos University, Muscat.
Harold SniederDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, The Netherlands.

Funding

SOLAR-Eclipse Computational Tools for Imaging GeneticsR01EB015611 · NIBIB · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI KOCHUNOV, PETER V. · 2012 to 2024
$5.0M
NIBIB NIH HHS R01 EB015611
6 · The paper itself

Abstract

objectiveTo more precisely and comprehensively estimate the genetic and environmental correlations between various indices of obesity and BP.

methodsWe estimated heritability and genetic correlations of obesity indices with BP in the Oman family study (n = 1231). Ambulatory and office beat-to-beat BP was measured and mean values for SBP and DBP during daytime, sleep, 24-h and 10 min at rest were calculated. Different indices were used to quantify obesity and fat distribution: BMI, percentage of body fat (%BF), waist circumference and waist-to-height ratio (WHtR). SOLAR software was used to perform univariate and bivariate quantitative genetic analyses adjusting for age, age, sex, age-sex and age--sex interactions.

resultsHeritabilities of BP ranged from 30.2 to 38.2% for ambulatory daytime, 16.8--21.4% for sleeping time, 32.1--40.4% for 24-h and 22--24.4% for office beat-to-beat measurements. Heritabilities for obesity indices were 67.8% for BMI, 52.2% for %BF, 37.3% for waist circumference and 37.9% for WHtR. All obesity measures had consistently positive phenotypic correlations with ambulatory and office beat-to-beat SBP and DBP (r-range: 0.14--0.32). Genetic correlations of obesity indices with SBP and DBP were higher than environmental correlations (rG: 0.16--0.50; rE: 0.01--0.31).

conclusionThe considerable genetic overlap between a variety of obesity indices and both ambulatory and office beat-to-beat BP highlights the relevance of pleiotropic genes. Future GWAS analyses should discover the specific genes both influencing obesity indices and BP to help unravel their shared genetic background.

Indexed as

Blood PressureObesityBlood Pressure Monitoring, AmbulatoryHumansOman

Identifiers

PMID32195815
PMCPMC7374053

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.