ArticleJournal of acquired immune deficiency syndromes (1999)2020
Cumulative Burden of Depression and Neurocognitive Decline Among Persons With HIV: A Longitudinal Study.
Article in Journal of acquired immune deficiency syndromes (1999), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Associations Between Depressive Symptoms and Memory Functions in Persons with HIV: A Systematic Review and Meta-Analysis.Neuropsychology review · 2026Pooled it
- Global Systematic Review of Common Mental Health Disorders in Adults Living with HIV.Current HIV/AIDS reports · 2021Pooled it
- When Being Social Is Costly: Empathy's Role for Risk States, Acute Symptoms, and Cumulative Disease Severity of Depression.Journal of clinical psychology · 2026Article
- Cumulative burden of depression and domain-specific cognitive impairment over time in the women's interagency HIV study: A marginal structural model approach.Journal of affective disorders · 2026Article
- Contrasting cannabinoid receptor 2 (CB2R)-mediated responses in two different models of Blood Brain Barrier in the context of HIV.Research square · 2025Article
- Medication literacy and treatment adherence in people living with human immunodeficiency virus: Mediating effects of psychosocial factors.World journal of psychiatry · 2025Review
- Predicting Trajectories of Everyday Functioning in Adults Aging with HIV Using Latent Growth Mixture Modeling.AIDS and behavior · 2025Article
- Self-reported everyday functioning among adults with human immunodeficiency virus: Longitudinal associations with global neurocognitive functioning and depressive symptoms.Journal of the International Neuropsychological Society : JINS · 2025Article
- Independent and combined adverse effects of neurocognitive impairment and depression on everyday functioning and quality of life in people with HIV.Journal of the International Neuropsychological Society : JINS · 2025Article
- HIV Stigma is Associated with Two-Year Decline in Cognitive Performance Among People with HIV.AIDS and behavior · 2025Article
- Lessons Learned from a Community-led, Pilot Teletherapy Group for Older Women Living with Depression and HIV.AIDS and behavior · 2024Article
- Neurocognition and its predictors in a linguistically and culturally diverse cohort of people with HIV.The Clinical neuropsychologist · 2024Article
- Identifying and distinguishing cognitive profiles among virally suppressed people with HIV.Neuropsychology · 2024Article
- Latent Profile Analysis of Cognitive Performance and Depressive Symptoms Among People with HIV.AIDS patient care and STDs · 2024Article
- Mild Cognitive Impairment, But Not HIV Status, is Related to Reduced Awareness of Level of Cognitive Performance Among Older Adults.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2023Article
- Longitudinal Associations of Psychiatric Risk Factors with Non-psychiatric Hospitalization in a Large Cohort of People Living with HIV in New York City.AIDS and behavior · 2023Article
- Verbal Memory Performance and Depressive Symptoms in Persons with Treated HIV.AIDS and behavior · 2023Article
- Neuropsychiatric predictors of cognitive functioning over a one-year follow-up period in HIV.Journal of affective disorders · 2023Article
- Article
- Twelve-year neurocognitive decline in HIV is associated with comorbidities, not age: a CHARTER study.Brain : a journal of neurology · 2023Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundHigher cumulative burden of depression among people with HIV (PWH) is associated with poorer health outcomes; however, longitudinal relationships with neurocognition are unclear. This study examined hypotheses that among PWH, (1) higher cumulative burden of depression would relate to steeper declines in neurocognition, and (2) visit-to-visit depression severity would relate to fluctuations in neurocognition within persons.
settingData were collected at a university-based research center from 2002 to 2016.
methodsParticipants included 448 PWH followed longitudinally. All participants had >1 visit (M = 4.97; SD = 3.53) capturing depression severity (Beck Depression Inventory-II) and neurocognition (comprehensive test battery). Cumulative burden of depression was calculated using an established method that derives weighted depression severity scores by time between visits and total time on study. Participants were categorized into low (67%), medium (15%), and high (18%) depression burden. Multilevel modeling examined between- and within-person associations between cumulative depression burden and neurocognition over time.
resultsThe high depression burden group demonstrated steeper global neurocognitive decline compared with the low depression burden group (b = -0.100, P = 0.001); this was driven by declines in executive functioning, delayed recall, and verbal fluency. Within-person results showed that compared with visits when participants reported minimal depressive symptoms, their neurocognition was worse when they reported mild (b = -0.12, P = 0.04) or moderate-to-severe (b = -0.15, P = 0.03) symptoms; this was driven by worsened motor skills and processing speed.
conclusionsHigh cumulative burden of depression is associated with worsening neurocognition among PWH, which may relate to poor HIV-related treatment outcomes. Intensive interventions among severely depressed PWH may benefit physical, mental, and cognitive health.
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