Evidence map›Paper›PMID 32195448›Full record

ArticleNeurobiology of sleep and circadian rhythms2020

Suprachiasmatic lesions restore object recognition in down syndrome model mice.

Bayarsaikhan Chuluun, Elsa Pittaras, Hyunseung Hong, Nathan Fisher, Damien Colas, Norman F Ruby, H Craig Heller

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of sleep and circadian rhythms, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. How did I come to sleep research and stay there?Sleep advances : a journal of the Sleep Research Society · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Bayarsaikhan ChuluunBiology Department, 371 Serra Mall, Stanford University, Stanford, CA, 94305-5020, USA.
Elsa PittarasBiology Department, 371 Serra Mall, Stanford University, Stanford, CA, 94305-5020, USA.
Hyunseung HongBiology Department, 371 Serra Mall, Stanford University, Stanford, CA, 94305-5020, USA.
Nathan FisherBiology Department, 371 Serra Mall, Stanford University, Stanford, CA, 94305-5020, USA.
Damien ColasBiology Department, 371 Serra Mall, Stanford University, Stanford, CA, 94305-5020, USA.
Norman F RubyBiology Department, 371 Serra Mall, Stanford University, Stanford, CA, 94305-5020, USA.
H Craig HellerBiology Department, 371 Serra Mall, Stanford University, Stanford, CA, 94305-5020, USA.
Stanford University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Ts65Dn mouse is a well-studied model of trisomy 21, Down syndrome. This mouse strain has severe learning disability as measured by several rodent learning tests that depend on hippocampal spatial memory function. Hippocampal long-term potentiation (LTP) is deficient in these mice. Short-term daily treatment with low-dose GABA receptor antagonists rescue spatial learning and LTP in Ts65Dn mice leading to the hypothesis that the learning disability is due to GABAergic over-inhibition of hippocampal circuits. The fact that the GABA receptor antagonists were only effective if delivered during the daily light phase suggested that the source of the excess GABA was controlled directly or indirectly by the circadian system. The central circadian pacemaker of mammals is the suprachiasmatic nucleus (SCN), which is largely a GABAergic nucleus. In this study we investigated whether elimination of the SCN in Ts65Dn mice would restore their ability to form recognition memories as tested by the novel object recognition (NOR) task. Full, but not partial lesions of the SCN of Ts65Dn mice normalized their ability to perform on the NOR test. These results suggest that the circadian system modulates neuroplasticity over the time frame involved in the process of consolidation of recognition memories.

Indexed as

Circadian rhythmsNovel object recognitionRecognition memoryTs65Dn mice

Identifiers

PMID32195448
PMCPMC7075983
OpenAlexW3006059639

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.