ArticleHeliyon2020
Comparison of fetal heart rate variability by symbolic dynamics at the third trimester of pregnancy and low-risk parturition.
Article in Heliyon, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Non-linear Methods Predominant in Fetal Heart Rate Analysis: A Systematic Review.Frontiers in medicine · 2021Pooled it
- Advanced Predictive Analytics for Fetal Heart Rate Variability Using Digital Twin Integration.Sensors (Basel, Switzerland) · 2025Article
- Optimizing Fall Risk Diagnosis in Older Adults Using a Bayesian Classifier and Simulated Annealing.Bioengineering (Basel, Switzerland) · 2024Article
- Analysis of fetal heart rate fluctuations in women diagnosed with preeclampsia during the latent phase of labor.Frontiers in physiology · 2024Article
- Characterization of the normal fetal circulatory system of the ductus venosus using sound complexity parameters.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2023Article
- Multiparametric Investigation of Dynamics in Fetal Heart Rate Signals.Bioengineering (Basel, Switzerland) · 2021Article
- Differences in the Asymmetry of Beat-to-Beat Fetal Heart Rate Accelerations and Decelerations at Preterm and Term Active Labor.Sensors (Basel, Switzerland) · 2021Observational
- A Comprehensive Review of Techniques for Processing and Analyzing Fetal Heart Rate Signals.Sensors (Basel, Switzerland) · 2021Review
- Phase Entropy Analysis of Electrohysterographic Data at the Third Trimester of Human Pregnancy and Active Parturition.Entropy (Basel, Switzerland) · 2020Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fetal heart rate variability (fHRV) is an essential source of information to monitor fetal well-being during pregnancy. This study aimed to apply a nonlinear approach, known as symbolic dynamics (SD), for comparing human fHRV in the third trimester of pregnancy during active fetal state (TT) and active labor at term (P). We performed a longitudinal, prospective, descriptive, and comparative study composed of 42 longitudinal recordings of 5-minutes of fetal heartbeat interval series. Recordings were collected from 21 low-risk, healthy, pregnant women attending the Maternal and Child Research Center (CIMIGen), Mexico City. We calculated relevant linear parameters of fHRV between TT and P stages, such as the percentage of differences between adjacent RR intervals >5 ms (PRR5, related to vagal modulations) and other SD parameters such as the percentage of no variations between three successive symbols (%0V, reflects sympathetic modulations) and the probability of low variability with a threshold of 4 ms (POLVAR4, associated with a low variability). We identified statistical differences for PRR5 between TT and P (37.13% [28.47-47.60%] vs. 28.84% [19.36-36.76%], p = 0.03), respectively. Also, for 0V% (65.66% [59.01-71.80%] vs. 71.14% [65.94-75.87%], p = 0.03) and for POLVAR4 values (0.06 [0.04-0.11] vs. 0.15 [0.09-0.24], p = 0.002), respectively. Our results indicate that during parturition, the short-term fetal fHRV is decreased, showing a decreased vagal modulations and higher adrenergic response of the heart. These autonomic modifications may result from the fetal response to the stressful inflammatory challenge of labor. We thus confirmed that the analysis of the SD applied to fHRV time series could be a potential clinical biomarker to differentiate the fetal autonomic cardiac condition at different stages of pregnancy.
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