Evidence map›Paper›PMID 32195383›Full record

ArticleHeliyon2020

Effects of senataxin and RNA exosome on B-cell chromosomal integrity.

David Kazadi, Junghyun Lim, Gerson Rothschild, Veronika Grinstein, Brice Laffleur, Olivier Becherel, Martin J Lavin, Uttiya Basu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

David KazadiDepartment of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Junghyun LimDepartment of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Gerson RothschildDepartment of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Veronika GrinsteinDepartment of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Brice LaffleurDepartment of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Olivier BecherelCentre for Clinical Research, University of Queensland, Brisbane, Qld, Australia.
Martin J LavinCentre for Clinical Research, University of Queensland, Brisbane, Qld, Australia.
Uttiya BasuDepartment of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Columbia University · USThe University of Queensland · AU

Funding

Role of ncRNA Surveillance Complex "RNA Exosome" in Class Switch Recombination and Somatic HypermutationR01AI099195 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Uttiya Basu · 2012 to 2026
$9.8M
Long noncoding RNA expressing genomic element that control antibody diversification and chromosomal integrity in B cellsR01AI134988 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Uttiya Basu · 2018 to 2026
$4.7M
NIAID NIH HHS R01 AI099195NIAID NIH HHS R01 AI134988
6 · The paper itself

Abstract

Loss of function of senataxin (SETX), a bona-fide RNA/DNA helicase, is associated with neuronal degeneration leading to Ataxia and Ocular Apraxia (AOA) in human patients. SETX is proposed to promote transcription termination, DNA replication, DNA repair, and to unwind deleterious RNA:DNA hybrids in the genome. In all the above-mentioned mechanisms, SETX unwinds transcription complex-associated nascent RNA which is then degraded by the RNA exosome complex. Here we have used B cells isolated from a SETX mutant mouse model and compared genomic instability and immunoglobulin heavy chain locus

Indexed as

BiochemistryBiological sciencesClass switch recombinationDNA/RNA hybridsGeneticsImmunologyMolecular biologyRNA exosomeSenataxin

Identifiers

PMID32195383
PMCPMC7075999
OpenAlexW3011471328

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.