Evidence map›Paper›PMID 32195326›Full record

ArticleTransplantation direct2020

Remote Therapy to Improve Outcomes in Lung Transplant Recipients: Design of the INSPIRE-III Randomized Clinical Trial.

James A Blumenthal, Patrick J Smith, Andrew Sherwood, Stephanie Mabe, Laurie Snyder, Courtney Frankel, Daphne C McKee, Natalie Hamilton, Francis J Keefe, Sheila Shearer and 2 more

Open access · goldAbstract read
In one paragraph

Article in Transplantation direct, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Telehealth interventions to improve outcomes in lung transplant recipients: Primary results of the INSPIRE-III randomized clinical trial.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2025
    Trial
  2. Article
  3. Article
  4. Observational
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

James A BlumenthalDepartment of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC.
Patrick J SmithDepartment of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC.
Andrew SherwoodDepartment of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC.
Stephanie MabeDepartment of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC.
Laurie SnyderDepartment of Medicine, Duke University Medical Center, Durham, NC.
Courtney FrankelDepartment of Medicine, Duke University Medical Center, Durham, NC.
Daphne C McKeeDepartment of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC.
Natalie HamiltonDepartment of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC.
Francis J KeefeDepartment of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC.
Sheila ShearerDepartment of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC.
Jeanne SchwartzDepartment of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC.
Scott PalmerDepartment of Medicine, Duke University Medical Center, Durham, NC.
Duke Medical Center · USDuke University Hospital · US

Funding

Improving Lung Transplant Outcomes with Coping Skills and Physical ActivityR01NR017801 · NINR · DUKE UNIVERSITY · PI PALMER, SCOTT M · 2019 to 2023
$3.1M
NINR NIH HHS R01 NR017801
6 · The paper itself

Abstract

backgroundImpaired functional capacity and emotional distress are associated with lower quality of life (QoL) and worse clinical outcomes in post lung transplant patients. Strategies to increase physical activity and reduce distress are needed.

methodsThe Investigational Study of Psychological Interventions in Recipients of Lung Transplant-III study is a single site, parallel group randomized clinical trial in which 150 lung transplant recipients will be randomly assigned to 3 months of telephone-delivered coping skills training combined with aerobic exercise (CSTEX) or to a Standard of Care plus Education control group. The primary endpoints are a global measure of distress and distance walked on the 6-Minute Walk Test. Secondary outcomes include measures of transplant-specific QoL, frailty, health behaviors, and chronic lung allograft dysfunction-free survival.

resultsParticipants will be evaluated at baseline, at the conclusion of 3 months of weekly treatment, at 1-year follow-up, and followed annually thereafter for clinical events for up to 4 years (median = 2 y). We also will determine whether functional capacity, distress, and health behaviors (eg, physical activity, medication adherence, and volume of air forcefully exhaled in 1 second (FEV1), mediate the effects of the CSTEX intervention on clinical outcomes.

conclusionsShould the CSTEX intervention result in better outcomes compared with the standard of care plus post-transplant education, the remotely delivered CSTEX intervention can be made available to all lung transplant recipients as a way of enhancing their QoL and improving clinical outcomes.

Identifiers

PMID32195326
PMCPMC7056276
OpenAlexW3007446920

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.