ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2020
4D Self-Morphing Culture Substrate for Modulating Cell Differentiation.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 77 citations in OpenAlex.
- cGAS-STING pathway modulation: A new hope for neural regeneration.Neural regeneration research · 2026Article
- Augmented 3D Printing for Multiscale Microphysiological Systems.Small (Weinheim an der Bergstrasse, Germany) · 2025Review
- Transformative bioprinting: 4D printing and its role in the evolution of engineering and personalized medicine.Discover nano · 2025Review
- 4D bioprinted self-folding scaffolds enhance cartilage formation in the engineering of trachea.Advanced materials technologies · 2025Article
- 4D fabrication of shape-changing systems for tissue engineering: state of the art and perspectives.Progress in additive manufacturing · 2025Review
- Silk Foams with Metallic Nanoparticles as Scaffolds for Soft Tissue Regeneration.International journal of molecular sciences · 2024Article
- Mechanobiomaterials: Harnessing mechanobiology principles for tissue repair and regeneration.Mechanobiology in medicine · 2024Review
- Long non-coding RNANeural regeneration research · 2024Article
- Injectable Bombyx mori (B. mori) silk fibroin/MXene conductive hydrogel for electrically stimulating neural stem cells into neurons for treating brain damage.Journal of nanobiotechnology · 2024Article
- Magnetically driven formation of 3D freestanding soft bioscaffolds.Science advances · 2024Article
- High Strength and Shape Memory Spinal Fusion Device for Minimally Invasive Interbody Fusions.International journal of nanomedicine · 2024Article
- Bioinspired thermadapt shape-memory polymer with light-induced reversible fluorescence for rewritable 2D/3D-encoding information carriers.Nature communications · 2023Article
- Harnessing three-dimensional (3D) cell culture models for pulmonary infections: State of the art and future directions.Naunyn-Schmiedeberg's archives of pharmacology · 2023Review
- Intelligent Vascularized 3D/4D/5D/6D-Printed Tissue Scaffolds.Nano-micro letters · 2023Review
- Prospects for the use of olfactory mucosa cells in bioprinting for the treatment of spinal cord injuries.World journal of clinical cases · 2023Review
- Four-Dimensional Printing and Shape Memory Materials in Bone Tissue Engineering.International journal of molecular sciences · 2023Review
- Smart implants: 4D-printed shape-morphing scaffolds for medical implantation.International journal of bioprinting · 2023Review
- 4D Thermo-Responsive Smart hiPSC-CM Cardiac Construct for Myocardial Cell Therapy.International journal of nanomedicine · 2023Article
- Article
- Highlights on Advancing Frontiers in Tissue Engineering.Tissue engineering. Part B, Reviews · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As the most versatile and promising cell source, stem cells have been studied in regenerative medicine for two decades. Currently available culturing techniques utilize a 2D or 3D microenvironment for supporting the growth and proliferation of stem cells. However, these culture systems fail to fully reflect the supportive biological environment in which stem cells reside in vivo, which contain dynamic biophysical growth cues. Herein, a 4D programmable culture substrate with a self-morphing capability is presented as a means to enhance dynamic cell growth and induce differentiation of stem cells. To function as a model system, a 4D neural culture substrate is fabricated using a combination of printing and imprinting techniques keyed to the different biological features of neural stem cells (NSCs) at different differentiation stages. Results show the 4D culture substrate demonstrates a time-dependent self-morphing process that plays an essential role in regulating NSC behaviors in a spatiotemporal manner and enhances neural differentiation of NSCs along with significant axonal alignment. This study of a customized, dynamic substrate revolutionizes current stem cell therapies, and can further have a far-reaching impact on improving tissue regeneration and mimicking specific disease progression, as well as other impacts on materials and life science research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.