Evidence map›Paper›PMID 32195074›Full record

ArticleChemistryOpen2020

Molecular Recognition by Zn(II)-Capped Dynamic Foldamers.

Natasha Eccles, Flavio Della Sala, Bryden A F Le Bailly, George F S Whitehead, Jonathan Clayden, Simon J Webb

Open access · goldAbstract read
In one paragraph

Article in ChemistryOpen, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Natasha EcclesDepartment of Chemistry University of Manchester Oxford Road Manchester M13 9PL UK.
Flavio Della SalaDepartment of Chemistry University of Manchester Oxford Road Manchester M13 9PL UK.
Bryden A F Le BaillyDepartment of Chemistry University of Manchester Oxford Road Manchester M13 9PL UK.
George F S WhiteheadDepartment of Chemistry University of Manchester Oxford Road Manchester M13 9PL UK.
Jonathan ClaydenSchool of Chemistry University of Bristol Cantock's Close Bristol BS8 1TS UK.
Simon J WebbDepartment of Chemistry University of Manchester Oxford Road Manchester M13 9PL UK.ORCID 0000-0001-9793-8748
University of Manchester · GBUniversity of Bristol · GB

Funding

Biotechnology and Biological Sciences Research Council
6 · The paper itself

Abstract

Two α-aminoisobutyric acid (Aib) foldamers bearing Zn(II)-chelating N-termini have been synthesized and compared with a reported Aib foldamer that has a bis(quinolinyl)/mono(pyridyl) cap (BQPA group). Replacement of the quinolinyl arms of the BQPA-capped foldamer with pyridyl gave a BPPA-capped foldamer, then further replacement of the linking pyridyl with a 1,2,3-triazole gave a BPTA-capped foldamer. Their ability to relay chiral information from carboxylate bound to Zn(II) at the N-terminus to a glycinamide-based NMR reporter of conformational preference at the C-terminus was measured. The importance of the quinolinyl arms became readily apparent, as the foldamers with pyridyl arms were unable to report on the presence of chiral carboxylate in acetonitrile. Low solubility, X-ray crystallography and

Indexed as

molecular recognitionpeptidesreceptorsself-assemblysupramolecular chemistry

Identifiers

PMID32195074
PMCPMC7080544
OpenAlexW3012532023

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.