Evidence map›Paper›PMID 32194993›Full record

ReviewCell death discovery2020

The role of noncoding RNAs in epithelial cancer.

Massimiliano Agostini, Carlo Ganini, Eleonora Candi, Gerry Melino

Open access · goldAbstract readReview
In one paragraph

Review in Cell death discovery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
3.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 64 citations in OpenAlex.

  1. Article
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  10. Article
  11. Hypoxia-driven ncRNAs in breast cancer.Frontiers in oncology · 2023
    Review
  12. Review
  13. Article
  14. Inflammation: A New Look at an Old Problem.International journal of molecular sciences · 2022
    Review
  15. Article
  16. Article
  17. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 2 countries.

Massimiliano Agostini1Department of Experimental Medicine, TOR, University of Rome "Tor Vergata", 00133 Rome, Italy.
Carlo Ganini1Department of Experimental Medicine, TOR, University of Rome "Tor Vergata", 00133 Rome, Italy.ORCID 0000-0002-5839-3965
Eleonora Candi1Department of Experimental Medicine, TOR, University of Rome "Tor Vergata", 00133 Rome, Italy.
Gerry Melino1Department of Experimental Medicine, TOR, University of Rome "Tor Vergata", 00133 Rome, Italy.
University of Rome Tor Vergata · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Regulatory noncoding RNAs (ncRNAs) are a class of RNAs transcribed by regions of the human genome that do not encode for proteins. The three main members of this class, named microRNA, long noncoding RNA, and circular RNA play a key role in the regulation of gene expression, eventually shaping critical cellular processes. Compelling experimental evidence shows that ncRNAs function either as tumor suppressors or oncogenes by participating in the regulation of one or several cancer hallmarks, including evading cell death, and their expression is frequently deregulated during cancer onset, progression, and dissemination. More recently, preclinical and clinical studies indicate that ncRNAs are potential biomarkers for monitoring cancer progression, relapse, and response to cancer therapy. Here, we will discuss the role of noncoding RNAs in regulating cancer cell death, focusing on those ncRNAs with a potential clinical relevance.

Indexed as

Long non-coding RNAsmiRNAs

Identifiers

PMID32194993
PMCPMC7067833
OpenAlexW3010704734

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.