Evidence map›Paper›PMID 32194962›Full record

ArticleClinical & translational immunology2020

Mucins and their receptors in chronic lung disease.

Emma Denneny, Jagdeep Sahota, Richard Beatson, David Thornton, Joy Burchell, Joanna Porter

Open access · goldAbstract read
In one paragraph

Article in Clinical & translational immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
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  3. Review
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  5. Article
  6. Review
  7. Article
  8. The HCoV-HKU1 N-terminal domain binds a wide range of 9-bioRxiv : the preprint server for biology · 2024
    Article
  9. Clonal Somatic Mutations in Chronic Lung Diseases Are Associated with Reduced Lung Function.American journal of respiratory and critical care medicine · 2023
    Article
  10. Review
  11. Steric pressure between glycosylated transmembrane proteins inhibits internalization by endocytosis.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  12. Prevalence and Mechanisms of Mucus Accumulation in COVID-19 Lung Disease.American journal of respiratory and critical care medicine · 2022
    Article
  13. Article
  14. Review
  15. Review
  16. Review
  17. Article
  18. Transmembrane Mucin 1 Blocks Fluorescein Ingress to Corneal Epithelium.Investigative ophthalmology & visual science · 2022
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Emma DennenyLeukocyte Trafficking Laboratory Centre for Inflammation and Tissue Repair UCL Respiratory Rayne Institute University College London London UK.ORCID https://orcid.org/0000-0002-7695-325X
Jagdeep SahotaLeukocyte Trafficking Laboratory Centre for Inflammation and Tissue Repair UCL Respiratory Rayne Institute University College London London UK.
Richard BeatsonBreast Cancer Biology Group Division of Cancer Studies King's College London Guy's Hospital London UK.
David ThorntonWellcome Trust Centre for Cell-Matrix Research School of Biological Sciences Faculty of Biology, Medicine and Health Manchester Academic Health Sciences Centre University of Manchester Manchester UK.ORCID https://orcid.org/0000-0001-7148-1970
Joy BurchellBreast Cancer Biology Group Division of Cancer Studies King's College London Guy's Hospital London UK.
Joanna PorterLeukocyte Trafficking Laboratory Centre for Inflammation and Tissue Repair UCL Respiratory Rayne Institute University College London London UK.
University College London · GBGuy's Hospital · GBWellcome Centre for Cell-Matrix Research · GB

Funding

Medical Research Council MR/K004158/1Medical Research Council MR/R002800/1
6 · The paper itself

Abstract

There is growing recognition that mucus and mucin biology have a considerable impact on respiratory health, and subsequent global morbidity and mortality. Mucins play a critical role in chronic lung disease, not only by providing a physical barrier and clearing pathogens, but also in immune homeostasis. The aim of this review is to familiarise the reader with the role of mucins in both lung health and disease, with particular focus on function in immunity, infection and inflammation. We will also discuss their receptors, termed glycan-binding proteins, and how they provide an attractive prospect for therapeutic intervention.

Indexed as

glycan‐binding proteinglycosylationimmunologymucinpulmonary

Identifiers

PMID32194962
PMCPMC7077995
OpenAlexW3011950774

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.