Evidence map›Paper›PMID 32194896›Full record

ArticleAmerican journal of translational research2020

Significant reduction in the LDL cholesterol increases the risk of intracerebral hemorrhage: a systematic review and meta-analysis of 33 randomized controlled trials.

Yao Cheng, Longwei Qiao, Zhibiao Jiang, Xiaofeng Dong, Hongxuan Feng, Qian Gui, Yaojuan Lu, Yuting Liang

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in American journal of translational research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

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  18. Stiffness of aortic arch and carotid arteries increases inAmerican journal of translational research · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Yao ChengDepartment of Neurology, The First Affiliated Hospital of Soochow University Suzhou 215000, Jiangsu Province, China.
Longwei QiaoCenter for Reproduction and Genetics, Suzhou Hospital Affiliated to Nanjing Medical University Suzhou 215002, Jiangsu Province, China.
Zhibiao JiangDepartment of Cardiac-Thoracic Surgery, Shanghai Fengxian District Central Hospital Shanghai 201499, China.
Xiaofeng DongDepartment of Neurology, Suzhou Hospital Affiliated to Nanjing Medical University Suzhou 215002, Jiangsu Province, China.
Hongxuan FengDepartment of Neurology, Suzhou Hospital Affiliated to Nanjing Medical University Suzhou 215002, Jiangsu Province, China.
Qian GuiDepartment of Neurology, Suzhou Hospital Affiliated to Nanjing Medical University Suzhou 215002, Jiangsu Province, China.
Yaojuan LuShenzhen Academy of Peptide Targeting Technology at Pingshan Shenzhen 518118, China.
Yuting LiangCenter of Clinical Laboratory, The First Affiliated Hospital of Soochow University Suzhou 215000, Jiangsu Province, China.
Suzhou Municipal Hospital · CNSoochow University · CNShenzhen Academy of Aerospace Technology · CNXian Central Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The dose-dependent pleiotropic effects of statin therapy may have unwanted side effects such as increasing the risk of intracerebral hemorrhage (ICH). The relationships among statin therapy, LDL-cholesterol levels, and ICH risk remain controversial. Here, we conduct a systematic review and meta-analysis of dose-dependent statin therapy and ICH risk. Eligible articles were identified by searching MEDLINE from inception up to December 1, 2018. Reference lists of previous meta-analyses were manually searched to retrieve all relevant publications. Statin doses were allocated into one of two groups according to the observed reduction of LDL cholesterol: doses that lowered LDL-cholesterol levels ≥35% were regarded as high-dose statin therapy, whereas those that lowered LDL-cholesterol levels <35% were regarded as low-dose statin therapy. We retrieved 33 studies involving 203,305 subjects. The pooled analysis indicated that high-dose statin treatment significantly increased the risk of ICH [relative risk (RR), 1.35; 95% confidence interval (CI), 1.08-1.68] and reduced the risk of all stroke (RR, 0.85; 95% CI, 0.78-0.92), ischemic stroke (RR, 0.79; 95% CI, 0.72-0.87), and all-cause mortality (RR, 0.94; 95% CI, 0.90-0.98). The analyses did not detect any association between low-dose statin treatment and ICH (RR, 1.05; 95% CI, 0.88-1.25). Low-dose statin therapy significantly reduced the incidence of all stroke (RR, 0.84; 95% CI, 0.79-0.89), ischemic stroke (RR, 0.81; 95% CI, 0.76-0.86), and all-cause mortality (RR, 0.94; 95% CI, 0.92-0.97). Our data indicate that low-dose statin therapy is a safe and effective ICH treatment, whereas high-dose statin therapy is associated with increased ICH risk. Hence, our meta-analysis suggests that the dose-dependent pleiotropic effects of statin therapy are related to the measured reduction in LDL cholesterol.

Indexed as

High-dose statin therapyintracerebral hemorrhagelow-dose statin therapymeta-analysis

Identifiers

PMID32194896
PMCPMC7061840
OpenAlexW3012697610

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.