Evidence map›Paper›PMID 32194873›Full record

ArticleTheranostics2020

ATRX/EZH2 complex epigenetically regulates FADD/PARP1 axis, contributing to TMZ resistance in glioma.

Bo Han, Xiangqi Meng, Pengfei Wu, Ziwei Li, Siyi Li, Yangong Zhang, Caijun Zha, Qile Ye, Chuanlu Jiang, Jinquan Cai and 1 more

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed, 2 pooled it
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

77 citing papers in PubMed, 2 syntheses or guidelines pooled it, 122 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. ATRX: From Chromatin Remodeling to Disease.Genesis (New York, N.Y. : 2000) · 2025
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Tumor heterogeneity and resistance in glioblastoma: the role of stem cells.Apoptosis : an international journal on programmed cell death · 2025
    Review
  16. Review
  17. Article
  18. Review
  19. Article
  20. Article

17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Bo HanBeijing Neurosurgical Institute, Capital Medical University, Beijing 100050, China.
Xiangqi MengDepartment of Neurosurgery, the Second Affiliated Hospital of Harbin Medical University, Neuroscience Institute, Heilongjiang Academy of Medical Sciences, Harbin 150086, China.
Pengfei WuDepartment of Neurosurgery, the Second Affiliated Hospital of Harbin Medical University, Neuroscience Institute, Heilongjiang Academy of Medical Sciences, Harbin 150086, China.
Ziwei LiDepartment of Neurosurgery, the Second Affiliated Hospital of Harbin Medical University, Neuroscience Institute, Heilongjiang Academy of Medical Sciences, Harbin 150086, China.
Siyi LiDepartment of Mining and Materials Engineering, McGill University, Montreal, QC H2X1X8, Canada.
Yangong ZhangDepartment of Neurosurgery, the Second Affiliated Hospital of Harbin Medical University, Neuroscience Institute, Heilongjiang Academy of Medical Sciences, Harbin 150086, China.
Caijun ZhaDepartment of Laboratory Diagnosis, the Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China.
Qile YeDepartment of Neurosurgery, the Second Affiliated Hospital of Harbin Medical University, Neuroscience Institute, Heilongjiang Academy of Medical Sciences, Harbin 150086, China.
Chuanlu JiangDepartment of Neurosurgery, the Second Affiliated Hospital of Harbin Medical University, Neuroscience Institute, Heilongjiang Academy of Medical Sciences, Harbin 150086, China.
Jinquan CaiDepartment of Neurosurgery, the Second Affiliated Hospital of Harbin Medical University, Neuroscience Institute, Heilongjiang Academy of Medical Sciences, Harbin 150086, China.
Tao JiangBeijing Neurosurgical Institute, Capital Medical University, Beijing 100050, China.
Second Affiliated Hospital of Harbin Medical University · CNBeijing Institute of Neurosurgery · CNCapital Medical University · CNHarbin Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

DNA MethylationAnimalsAntineoplastic Agents, AlkylatingBrain NeoplasmsCRISPR-Cas SystemsDioxygenasesDNA-Binding ProteinsDNA DamageDNA, NeoplasmDNA RepairDrug Resistance, NeoplasmEnhancer of Zeste Homolog 2 ProteinFas-Associated Death Domain ProteinGene EditingGene Expression Regulation, NeoplasticGene Knockout TechniquesAntineoplastic Agents, AlkylatingATRX protein, humanDioxygenasesDNA-Binding ProteinsDNA, NeoplasmEnhancer of Zeste Homolog 2 ProteinEZH2 protein, humanFADD protein, humanFas-Associated Death Domain ProteinNeoplasm ProteinsPARP1 protein, humanPoly (ADP-Ribose) Polymerase-1Proto-Oncogene ProteinsSTAT5B protein, humanSTAT5 Transcription FactorTemozolomideTET2 protein, humanX-linked Nuclear ProteinATRXEZH2gliomaPARP1TMZ resistance

Identifiers

PMID32194873
PMCPMC7053195
OpenAlexW3006191171

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.