Evidence map›Paper›PMID 32194872›Full record

ArticleTheranostics2020

Detection of Lymph Node Metastases by Ultra-pH-Sensitive Polymeric Nanoparticles.

Zachary T Bennett, Qiang Feng, Justin A Bishop, Gang Huang, Baran D Sumer, Jinming Gao

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Zachary T BennettDepartment of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Qiang FengDepartment of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Justin A BishopDepartment of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Gang HuangDepartment of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Baran D SumerDepartment of Otolaryngology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Jinming GaoDepartment of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
The University of Texas Southwestern Medical Center · US

Funding

Nanoprobe-enabled Delineation of Tumor Margins for Improved Surgical TherapyR01CA192221 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI GAO, JINMING, SUMER, BARAN D · 2015 to 2019
$1.8M
pH Transistor Nanoprobes for Detection of Occult Nodal MetastasesR01CA211930 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI GAO, JINMING, SUMER, BARAN D · 2017 to 2021
$1.8M
NCI NIH HHS R01 CA192221NCI NIH HHS R01 CA211930
6 · The paper itself

Abstract

Lymph node (LN) dissection followed by histological analysis is the current standard for diagnosis of LN metastasis but the method suffers from patient morbidity and low sensitivity of detection. Ultra-pH sensitive (UPS) nanoparticles show remarkable accuracy in the delineation of primary tumor margins for precision cancer surgery. Herein we investigate the effectiveness of UPS nanoparticles to detect cancer-involved LNs.

Indexed as

AcidosisAnimalsArea Under CurveComputer SystemsDynamic Light ScatteringFemaleFluorometryHydrogen-Ion ConcentrationIndocyanine GreenLymphatic MetastasisLymph Node ExcisionLymph NodesMacrophagesMammary Neoplasms, ExperimentalMiceMice, Inbred BALB CIndocyanine GreenMicellesImage-guided surgeryLymph node metastasisPolymeric micelle

Identifiers

PMID32194872
PMCPMC7053196
OpenAlexW3006116529

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.