Evidence map›Paper›PMID 32194854›Full record

ArticleTheranostics2020

Targeting CAMKII to reprogram tumor-associated macrophages and inhibit tumor cells for cancer immunotherapy with an injectable hybrid peptide hydrogel.

Xiaomeng Dai, Jingshu Meng, Suke Deng, Lingling Zhang, Chao Wan, Lisen Lu, Jing Huang, Yan Hu, Zhanjie Zhang, Yan Li and 4 more

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 1 synthesis or guideline pooled it, 81 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. SPP1Cell death & disease · 2026
    Article
  4. Article
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  12. Article
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  14. Article
  15. The complex role of IL-10 in malignant ascites: a review.Cancer immunology, immunotherapy : CII · 2024
    Review
  16. Review
  17. Drug delivery methods for cancer immunotherapy.Drug delivery and translational research · 2024
    Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 2 countries.

Xiaomeng DaiCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Jingshu MengCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Suke DengCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Lingling ZhangCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Chao WanCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Lisen LuCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Jing HuangCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Yan HuCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Zhanjie ZhangCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Yan LiCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Jonathan F LovellDepartment of Chemical and Biological Engineering, University at Buffalo, State University of New York. Buffalo, New York 14260, USA.
Gang WuCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Kunyu YangCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Honglin JinCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Union Hospital · CNHuazhong University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Simultaneously targeted treatment of tumor cells and their surrounding growth-supporting immune cells is a promising strategy to reshape immunosuppressive tumor microenvironment (TME) and potentiate host innate and adaptive antitumor immune responses.

Indexed as

Amino Acid SequenceAnimalsAntineoplastic AgentsAscitesB7-H1 AntigenBenzenesulfonamidesBenzylaminesCalcium-Calmodulin-Dependent Protein Kinase Type 2Cellular Reprogramming TechniquesDrug CompoundingDrug Screening Assays, AntitumorFemaleHydrogelsImmunotherapyInjections, IntraperitonealLiver Neoplasms, ExperimentalAntineoplastic AgentsB7-H1 AntigenBenzenesulfonamidesBenzylaminesCalcium-Calmodulin-Dependent Protein Kinase Type 2Cd274 protein, mouseHydrogelsKN 93MelittenNeoplasm ProteinsOligopeptidesProtein Kinase InhibitorsRecombinant Fusion ProteinsSulfonamidesanti-PD-1CAMKIIcancer immunotherapyHydrogeltumor-associated macrophages

Identifiers

PMID32194854
PMCPMC7053188
OpenAlexW3005576772

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.