Evidence map›Paper›PMID 32194558›Full record

ArticleFrontiers in immunology2020

CCL3/Macrophage Inflammatory Protein-1α Is Dually Involved in Parasite Persistence and Induction of a TNF- and IFNγ-Enriched Inflammatory Milieu in

Daniel Gibaldi, Glaucia Vilar-Pereira, Isabela Resende Pereira, Andrea Alice Silva, Leda Castaño Barrios, Isalira Peroba Ramos, Hílton Antônio Mata Dos Santos, Ricardo Gazzinelli, Joseli Lannes-Vieira

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 49 citations in OpenAlex.

  1. Article
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  7. Bystander CD8Frontiers in immunology · 2025
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  14. CCR5 promotes the migration of CD8bioRxiv : the preprint server for biology · 2023
    Article
  15. Article
  16. Review
  17. Theracurmin Modulates Cardiac Inflammation in Experimental Model ofTropical medicine and infectious disease · 2023
    Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Daniel GibaldiLaboratório de Biologia das Interações, Instituto Oswaldo Cruz (Fiocruz), Rio de Janeiro, Brazil.
Glaucia Vilar-PereiraLaboratório de Biologia das Interações, Instituto Oswaldo Cruz (Fiocruz), Rio de Janeiro, Brazil.
Isabela Resende PereiraLaboratório de Biologia das Interações, Instituto Oswaldo Cruz (Fiocruz), Rio de Janeiro, Brazil.
Andrea Alice SilvaLaboratório Multiusuário de Apoio à Pesquisa em Nefrologia e Ciências Médicas, Departamento de Patologia, Faculdade de Medicina, Universidade Federal Fluminense, Rio de Janeiro, Brazil.
Leda Castaño BarriosLaboratório de Biologia das Interações, Instituto Oswaldo Cruz (Fiocruz), Rio de Janeiro, Brazil.
Isalira Peroba RamosLaboratório de Cardiologia Celular e Molecular, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Hílton Antônio Mata Dos SantosFaculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Ricardo GazzinelliDepartamento de Bioquímica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Joseli Lannes-VieiraLaboratório de Biologia das Interações, Instituto Oswaldo Cruz (Fiocruz), Rio de Janeiro, Brazil.
Fundação Oswaldo Cruz · BRUniversidade Federal do Rio de Janeiro · BRUniversidade Federal de Minas Gerais · BRUniversidade Federal Fluminense · BR

Funding

Granzyme and Granulysin Mediated Death of Trypanosoma cruziR01AI116577 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI GAZZINELLI, RICARDO TOSTES, LIEBERMAN, JUDY · 2016 to 2020
$3.2M
NIAID NIH HHS R01 AI116577
6 · The paper itself

Abstract

CCL3, a member of the CC-chemokine family, has been associated with macrophage recruitment to heart tissue and parasite control in the acute infection of mouse with

Indexed as

AnimalsCD8-Positive T-LymphocytesCells, CulturedChagas CardiomyopathyChemokine CCL3Chemokine CCL5Chemotaxis, LeukocyteCytokinesElectrocardiographyFemaleInterferon-gammaMacrophages, PeritonealMaleMiceMice, Inbred C57BLMice, KnockoutCcl3 protein, mouseChemokine CCL3Chemokine CCL5CytokinesIFNG protein, mouseInterferon-gammaRANTES, Met-Receptors, ChemokineRNA, MessengerTumor Necrosis Factor-alphaCCL3cell migrationChagas diseaseheart diseaseIFNγMet-RANTESQTc prolongationTNF

Identifiers

PMID32194558
PMCPMC7063958
OpenAlexW3009337990

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.