Evidence map›Paper›PMID 32194549›Full record

ArticleFrontiers in immunology2020

Impact of BAFF Blockade on Inflammation, Germinal Center Reaction and Effector B-Cells During Acute SIV Infection.

Gwenoline Borhis, Maria Trovato, Hany M Ibrahim, Stephane Isnard, Roger Le Grand, Nathalie Bosquet, Yolande Richard

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 1 country.

Gwenoline BorhisUniversité de Paris, Institut Cochin, INSERM, CNRS, Paris, France.
Maria TrovatoUniversité de Paris, Institut Cochin, INSERM, CNRS, Paris, France.
Hany M IbrahimUniversité de Paris, Institut Cochin, INSERM, CNRS, Paris, France.
Stephane IsnardUniversité de Paris, Institut Cochin, INSERM, CNRS, Paris, France.
Roger Le GrandCEA, Université Paris Sud, INSERM U1184, Immunology of Viral Infections and Autoimmune Diseases (IMVA), IDMIT Department/IBFJ, Fontenay-aux-Roses, France.
Nathalie BosquetCEA, Université Paris Sud, INSERM U1184, Immunology of Viral Infections and Autoimmune Diseases (IMVA), IDMIT Department/IBFJ, Fontenay-aux-Roses, France.
Yolande RichardUniversité de Paris, Institut Cochin, INSERM, CNRS, Paris, France.
Centre National de la Recherche Scientifique · FRCommissariat à l'Énergie Atomique et aux Énergies Alternatives · FRInserm · FRInstitut Cochin · FRUniversité Paris Cité · FRUniversité Paris-Sud · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Memory B-cell dysfunctions and inefficient antibody response suggest germinal center (GC) impairments during HIV/SIV infection with possible contribution of overproduced B-cell activating factor (BAFF). To address this question, we compared proportions and functions of various B-cell subsets and follicular helper T-cells (T

Indexed as

Acute DiseaseAnimalsB-Cell Activating FactorB-Cell Activation Factor ReceptorB-LymphocytesCD4-Positive T-LymphocytesCytokinesGerminal CenterHIV-1HIV InfectionsHumansImmunoglobulin Fc FragmentsImmunologic MemoryInflammationInflammation MediatorsMacaca fascicularisB-Cell Activating FactorB-Cell Activation Factor ReceptorCytokinesImmunoglobulin Fc FragmentsInflammation MediatorsRecombinant Fusion ProteinsBAFFB-cellsCXCL13GCmemory B-cellspDCSIVTFH

Identifiers

PMID32194549
PMCPMC7061218
OpenAlexW3010565113

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.