Evidence map›Paper›PMID 32194543›Full record

ArticleFrontiers in immunology2020

Delineation of Homeostatic Immune Signatures Defining Viremic Non-progression in HIV-1 Infection.

Amit Kumar Singh, Sukeshani Salwe, Varsha Padwal, Shilpa Velhal, Jyoti Sutar, Shilpa Bhowmick, Srabani Mukherjee, Vidya Nagar, Priya Patil, Vainav Patel

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Amit Kumar SinghDepartment of Biochemistry and Virology, Indian Council of Medical Research (ICMR)-National Institute for Research in Reproductive Health, Mumbai, India.
Sukeshani SalweDepartment of Biochemistry and Virology, Indian Council of Medical Research (ICMR)-National Institute for Research in Reproductive Health, Mumbai, India.
Varsha PadwalDepartment of Biochemistry and Virology, Indian Council of Medical Research (ICMR)-National Institute for Research in Reproductive Health, Mumbai, India.
Shilpa VelhalDepartment of Biochemistry and Virology, Indian Council of Medical Research (ICMR)-National Institute for Research in Reproductive Health, Mumbai, India.
Jyoti SutarDepartment of Biochemistry and Virology, Indian Council of Medical Research (ICMR)-National Institute for Research in Reproductive Health, Mumbai, India.
Shilpa BhowmickDepartment of Biochemistry and Virology, Indian Council of Medical Research (ICMR)-National Institute for Research in Reproductive Health, Mumbai, India.
Srabani MukherjeeDepartment of Molecular Endocrinology, Indian Council of Medical Research (ICMR)-National Institute for Research in Reproductive Health, Mumbai, India.
Vidya NagarDepartment of Medicine, Grant Medical College & Sir J. J. Group of Hospitals, Mumbai, India.
Priya PatilDepartment of Medicine, Grant Medical College & Sir J. J. Group of Hospitals, Mumbai, India.
Vainav PatelDepartment of Biochemistry and Virology, Indian Council of Medical Research (ICMR)-National Institute for Research in Reproductive Health, Mumbai, India.
National Institute for Research in Reproductive Health · INGrant Medical College and Sir Jamshedjee Jeejeebhoy Group of Hospitals · INIndian Council of Medical Research · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Viremic non-progressors (VNPs), a distinct group of HIV-1-infected individuals, exhibit no signs of disease progression and maintain persistently elevated CD4+ T cell counts for several years despite high viral replication. Comprehensive characterization of homeostatic cellular immune signatures in VNPs can provide unique insights into mechanisms responsible for coping with viral pathogenesis as well as identifying strategies for immune restoration under clinically relevant settings such as antiretroviral therapy (ART) failure. We report a novel homeostatic signature in VNPs, the preservation of the central memory CD4+ T cell (CD4+ T

Indexed as

Disease ProgressionHIV Long-Term SurvivorsAdolescentAdultCD4 Lymphocyte CountCD8-Positive T-LymphocytesFemaleGenotypeHIV-1HIV SeropositivityHomeostasisHumansInterleukin-7MaleMiddle AgedReceptors, Interleukin-7IL7 protein, humanInterleukin-7interleukin-7 receptor, alpha chainReceptors, Interleukin-7CD4+ central memorydisease progressionHIV-1homeostasisimmune activationlong-term non-progressorsviral pathogenesisviremic non-progressors

Identifiers

PMID32194543
PMCPMC7066316
OpenAlexW3009663304

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.