Evidence map›Paper›PMID 32194353›Full record

ReviewReports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology

Cancer cells resist hyperthermia due to its obstructed activation of caspase 3.

Xiaoren Tang, Feng Cao, Weiyuan Ma, Yinian Tang, Bushra Aljahdali, Mansour Alasir, I Erdjan Salih, Serge Dibart

Open access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Xiaoren TangHenry M. Goldman School of Dental Medicine, Department of Periodontology, 650 Albany Street, Boston, MA, USA.
Feng CaoHenry M. Goldman School of Dental Medicine, Department of Periodontology, 650 Albany Street, Boston, MA, USA.
Weiyuan MaDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, MA, USA.
Yinian TangSchool of Medicine, Boston University, 72 East Concord St, Boston, MA, USA.
Bushra AljahdaliHenry M. Goldman School of Dental Medicine, Department of Periodontology, 650 Albany Street, Boston, MA, USA.
Mansour AlasirHenry M. Goldman School of Dental Medicine, Department of Periodontology, 650 Albany Street, Boston, MA, USA.
I Erdjan SalihHenry M. Goldman School of Dental Medicine, Department of Periodontology, 650 Albany Street, Boston, MA, USA.
Serge DibartHenry M. Goldman School of Dental Medicine, Department of Periodontology, 650 Albany Street, Boston, MA, USA.
Boston University · USHarvard University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimIt is well known that inducing hyperthermia is a type of cancer treatment but some research groups indicate that this treatment is not effective. This article finds and explains the mechanism of this treatment and its possible problems.

backgroundHyperthermia is commonly known as a state when the temperature of the body rises to a level that can threaten one's health. Hyperthermia is a type of cancer treatment in which body tissue is exposed to high temperatures (up to 45 °C). Research has shown that high temperatures can damage and kill cancer cells, usually with minimal injury to normal tissues. However, this mechanism is not known. MATERIALS AND

methodsWe recently treated cancer cells with different temperatures ranging from 37 °C to 47 °C and further measured their caspase 3 secretion by ELISA, western blot and cell survival rate by microscope.

resultsWe found that most cancer cells are able to resist hyperthermia more than normal cells most likely via non-activation of caspase3. We also found that hyperthermia-treated (≥41°) cancer cells extend a long pseudopod-like extension in comparison to the same cancer cells under normal conditions.

conclusionOur data here indicates that cancer cells have resistance to higher temperatures compared to normal cells via non-activation of caspase 3. This is a significant issue that needs to be brought to attention as the medical community has always believed that a high temperature treatment can selectively kill cancer/tumor cells. Additionally, we believe that the pseudopod-like extensions of hyperthermia-treated cancer cells must be related to its resistance to hyperthermia.

Indexed as

Cancer cells resist hyperthermia

Identifiers

PMID32194353
PMCPMC7078503
OpenAlexW3008154191

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.