ArticleSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society2020
Molecular interaction of tea catechin with bovine β-lactoglobulin: A spectroscopic and in silico studies.
Article in Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 95 citations in OpenAlex.
- Interaction differences between selected sweet-fragrant aroma compounds and different salivary proteins: Effects of molecular structure.Food chemistry: X · 2026Article
- Effects of Tea Polyphenols and Thermal Pretreatment on the Gel Properties and Storage Stability of Yogurt.Foods (Basel, Switzerland) · 2026Article
- From rumen to milk: Dietary polyphenols in dairy cows-A critical review.Veterinary and animal science · 2026Review
- Development, nutritional profiling, physicochemical properties, computational protein-polyphenol interactions, and sensory properties of high-energy Medjool date bars.Frontiers in nutrition · 2026Article
- Comparative study of the interaction between β-lactoglobulin and three carotenoids.Current research in food science · 2026Article
- Study on the astringent mechanism ofFood chemistry: X · 2025Article
- Process-Induced Molecular-Level Protein-Carbohydrate-Polyphenol Interactions in Milk-Tea Blends: A Review.Foods (Basel, Switzerland) · 2024Review
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- Characterization of walnut protein isolate-polyphenol nanoconjugates for the developing a food-grade delivery system.Journal of food science and technology · 2023Article
- Probing the binding of morin with alpha-2-macroglobulin using multi-spectroscopic and molecular docking approach : Interaction of morin with αJournal of biological physics · 2023Article
- Study on the Interaction Mechanism of Theaflavin with Whey Protein: Multi-Spectroscopy Analysis and Molecular Docking.Foods (Basel, Switzerland) · 2023Article
- The repercussions of digital bullying on social media users.Frontiers in psychology · 2023Article
- Alpha-glucosidase inhibitors fromSaudi journal of biological sciences · 2022Article
- Alleviating Aspirin-Induced Gastric Injury by Binding Aspirin to β-Lactoglobulin.Drug design, development and therapy · 2022Article
- Spectroscopic and Theoretical Investigation of β-Lactoglobulin Interactions with Hematoporphyrin and Protoporphyrin IX.ACS omega · 2021Article
- Spectroscopic and molecular docking studies for characterizing binding mechanism and conformational changes of human serum albumin upon interaction with Telmisartan.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2020Article
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Authors and funding
8 authors at 2 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
Polyphenols has attained pronounced attention due to their beneficial values of health and found to prevent several chronic diseases. Here, we elucidated binding mechanism between frequently consumed polyphenol "tea catechin" and milk protein bovine beta-lactoglobulin (β-Lg). We investigated the conformational changes of β-Lg due to interaction with catechin using spectroscopic and in silico studies. Fluorescence quenching data (Stern-Volmer quenching constant) revealed that β-Lg interacted with catechin via dynamic quenching. Thermodynamic data revealed that the interaction between β-Lg and catechin is endothermic and spontaneously interacted mainly through hydrophobic interactions. The UV-Vis absorption and far-UV circular dichroism (CD) spectroscopy exhibited that the tertiary as well as secondary structure of β-Lg distorted after interaction with catechin. Molecular docking and simulation studies also confirm that catechin binds at the central cavity of β-Lg with high affinity (~10
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