ArticleChinese journal of cancer research = Chung-kuo yen cheng yen chiu2020
Spectral CT imaging parameters and Ki-67 labeling index in lung adenocarcinoma.
Article in Chinese journal of cancer research = Chung-kuo yen cheng yen chiu, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 24 citations in OpenAlex.
- Development of a nomogram for predicting extramural venous invasion in colon cancer using spectral CT multiparameter imaging.Cancer imaging : the official publication of the International Cancer Imaging Society · 2026Article
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- Dual-layer spectral detector CT: a non-invasive tool for simultaneously predicting Ki-67 proliferation status and p53 mutations in pancreatic ductal adenocarcinoma.Abdominal radiology (New York) · 2026Article
- Identification of PD-L1 Expression in Resectable NSCLC using Interpretable Machine Learning Model Based on Spectral CTCurrent medical imaging · 2025Article
- Predictive value of spectral dual-detector computed tomography forQuantitative imaging in medicine and surgery · 2024Article
- Factors correlating the expression of PD-L1.BMC cancer · 2024Article
- Dual-energy CT improves differentiation of non-hypervascular pancreatic neuroendocrine neoplasms from CA 19-9-negative pancreatic ductal adenocarcinomas.La Radiologia medica · 2024Article
- Clinical value of dual-energy CT for predicting occult metastasis in central neck lymph nodes of papillary thyroid carcinoma.European radiology · 2024Article
- Differentiating invasive thymic epithelial tumors from mediastinal lung cancer using spectral CT parameters.Japanese journal of radiology · 2023Article
- Quantitative parameters in novel spectral computed tomography: Assessment of Ki-67 expression in patients with gastric adenocarcinoma.World journal of gastroenterology · 2023Article
- Correlation between apparent diffusion coefficient and Ki-67 in different pathological types of lung cancer.Translational cancer research · 2021Article
- Iodine-related attenuation in contrast-enhanced dual-energy computed tomography in small-sized solid-type lung cancers is associated with the postoperative prognosis.Cancer imaging : the official publication of the International Cancer Imaging Society · 2021Article
- Pre-operative Prediction of Ki-67 Expression in Various Histological Subtypes of Lung Adenocarcinoma Based on CT Radiomic Features.Frontiers in surgery · 2021Article
- Relationship Between Ultrasound Features and Ki-67 Labeling Index of Soft Tissue Sarcoma.Frontiers in oncology · 2021Article
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5 authors at 1 institution in 1 country.
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Abstract
objectiveTo explore the correlation between the spectral computed tomography (CT) imaging parameters and the Ki-67 labeling index in lung adenocarcinoma.
methodsSpectral CT imaging parameters [iodine concentrations of lesions (ICLs) in the arterial phase (ICLa) and venous phase (ICLv), normalized IC in the aorta (NICa/NICv), slope of the spectral HU curve (λHUa/λHUv) and monochromatic CT number enhancement on 40 keV and 70 keV images (CT40keVa/v, CT70keVa/v)] in 34 lung adenocarcinomas were analyzed, and common molecular markers, including the Ki-67 labeling index, were detected with immunohistochemistry. Different Ki-67 labeling indexes were measured and grouped into four grades according to the number of positive-stained cells (grade 0, ≤1%; 1%<grade 1≤10%; 10%<grade 2≤30%; and grade 3, >30%). One-way analysis of variance (ANOVA) was used to compare the four different grades, and the Bonferroni method was used to correct the P value for multiple comparisons. A Spearman correlation analysis was performed to further research a quantitative correlation between the Ki-67 labeling index and spectral CT imaging parameters.
resultsCT40keVa, CT40keVv, CT70keVa and CT70keVv increased as the grade increased, and CT70keVa and CT70keVv were statistically significant (P<0.05). These four parameters and the Ki-67 labeling index showed a moderate positive correlation with lung adenocarcinoma nodules. ICL, NIC and λHU in the arterial and venous phases were not significantly different among the four grades.
conclusionsThe spectral CT imaging parameters CT40keVa, CT40keVv, CT70keVa and CT70keVv gradually increased with Ki-67 expression and showed a moderate positive correlation with lung adenocarcinomas. Therefore, spectral CT imaging parameter-enhanced monochromatic CT numbers at 70 keV may indicate the extent of proliferation of lung adenocarcinomas.
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