Evidence map›Paper›PMID 32194307›Full record

ArticleChinese journal of cancer research = Chung-kuo yen cheng yen chiu2020

Tumor-associated macrophages regulate gastric cancer cell invasion and metastasis through TGFβ2/NF-κB/Kindlin-2 axis.

Zhu Wang, Yang Yang, Yancheng Cui, Chao Wang, Zhiyong Lai, Yansen Li, Wei Zhang, Harri Mustonen, Pauli Puolakkainen, Yingjiang Ye and 3 more

Erratum issuedOpen access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chinese journal of cancer research = Chung-kuo yen cheng yen chiu, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 38 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 1 pooled it
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.

  1. Pooled it
  2. Association ofTranslational cancer research · 2026
    Article
  3. Review
  4. Article
  5. Dysregulated macrophage immunity inFrontiers in immunology · 2025
    Review
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  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Zhu WangDepartment of Gastroenterological Surgery, Peking University People's Hospital, Beijing 100044, China.
Yang YangDepartment of Gastroenterological Surgery, Peking University People's Hospital, Beijing 100044, China.
Yancheng CuiDepartment of Gastroenterological Surgery, Peking University People's Hospital, Beijing 100044, China.
Chao WangDepartment of Gastroenterological Surgery, Peking University People's Hospital, Beijing 100044, China.
Zhiyong LaiDepartment of Gastroenterological Surgery, Peking University People's Hospital, Beijing 100044, China.
Yansen LiDepartment of Gastroenterological Surgery, Peking University People's Hospital, Beijing 100044, China.
Wei ZhangDepartment of Gastroenterological Surgery, Peking University People's Hospital, Beijing 100044, China.
Harri MustonenDepartment of Surgery, Helsinki University Central Hospital, and University of Helsinki, Helsinki 00290, Finland.
Pauli PuolakkainenDepartment of Surgery, Helsinki University Central Hospital, and University of Helsinki, Helsinki 00290, Finland.
Yingjiang YeDepartment of Gastroenterological Surgery, Peking University People's Hospital, Beijing 100044, China.
Kewei JiangDepartment of Gastroenterological Surgery, Peking University People's Hospital, Beijing 100044, China.
Zhanlong ShenDepartment of Gastroenterological Surgery, Peking University People's Hospital, Beijing 100044, China.
Shan WangDepartment of Gastroenterological Surgery, Peking University People's Hospital, Beijing 100044, China.
Peking University People's Hospital · CNPeking University · CNHelsinki University Hospital · FIUniversity of Helsinki · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveRecent studies have shown that tumor-associated macrophages (TAMs) play an important role in cancer invasion and metastasis. Our previous studies have reported that TAMs promote the invasion and metastasis of gastric cancer (GC) cells through the Kindlin-2 pathway. However, the mechanism needs to be clarified.

methodsTHP-1 monocytes were induced by PMA/interleukin (IL)-4/IL-13 to establish an efficient TAM model

resultsWe found that Kindlin-2 expression was upregulated at both mRNA and protein levels in GC cells cocultured with TAMs, associated with higher invasion rate. Kindlin-2 knockdown reduced the invasion rate of GC cells under coculture condition. TGFβ2 secreted by TAMs regulated the expression of Kindlin-2 through the transcription factor NF-кB. TAMs thus participated in the progression of GC through the TGFβ2/NF-κB/Kindlin-2 axis. Kindlin-2 expression and TAM infiltration were significantly positively correlated with TNM stage, and patients with high Kindlin-2 expression had significantly poorer overall survival than patients with low Kindlin-2 expression. Furthermore, Kindlin-2 promoted the invasion of GC cells

conclusionsThis study elucidates the mechanism of TAMs participating in GC cell invasion and metastasis through the TGFβ2/NF-κB/Kindlin-2 axis, providing a possibility for new treatment options and approaches.

Indexed as

Gastric cancerinvasion and metastasisKindlin-2tumor-associated macrophage

Identifiers

PMID32194307
PMCPMC7072013
OpenAlexW3011803995

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.