Evidence map›Paper›PMID 32194293›Full record

ArticleTrends in analytical chemistry : TRAC2020

Translating in vitro diagnostics from centralized laboratories to point-of-care locations using commercially-available handheld meters.

JingJing Zhang, Tian Lan, Yi Lu

Registry-linked trialAbstract read
In one paragraph

Article in Trends in analytical chemistry : TRAC, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05048472 (Implementation of Point of Care HIV Viral Load Monitoring to Improve Viral Load Suppression Among Children, Adolescents and Young People Living With HIV in East Africa), which is not on this map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05048472 nacompletednot on this mapstarted 2022, after this paper: background citation

Implementation of Point of Care HIV Viral Load Monitoring to Improve Viral Load Suppression Among Children, Adolescents and Young People Living With HIV in East Africa

TypeinterventionalSponsorMRC/UVRI and LSHTM Uganda Research UnitRan2022 to 2025Enrolled956ConditionsHIV, Viral Load, Point of Care MonitoringArmsAbbott HIV-1/2 VL Point of care Device
3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Ratiometric Detection of ZnChemistry (Basel, Switzerland) · 2023
    Article
  13. Review
  14. Device integration of electrochemical biosensors.Nature reviews bioengineering · 2023
    Review
  15. Review
  16. Article
  17. Article
  18. Biosensing with DNAzymes.Chemical Society reviews · 2021
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

JingJing ZhangState Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.
Tian LanGlucoSentient, Inc., 2100 S. Oak Street, Suite 101, Champaign, IL 61820, USA.
Yi LuDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.

Funding

Selection and Sensing Applications of DNAzymes Selective for Paramagnetic Metal IonsR01GM124316 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI LU, YI · 2017 to 2020
$1.4M
Novel DNAzyme sensors for lithium and sodium to understand cellular and molecular mechanisms of lithium treatment of bipolar disorderR21MH110975 · NIMH · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI LU, YI · 2016 to 2017
$401k
Point-of-care assay using Blood Glucose Meter for early warning of chronic lung rejectionR43HL142326 · NHLBI · GLUCOSENTIENT, INC. · PI LAN, TIAN · 2018 to 2018
$225k
NHLBI NIH HHS R43 HL142326NIGMS NIH HHS R01 GM124316NIMH NIH HHS R21 MH110975
6 · The paper itself

Abstract

There is a growing demand for high-performance point-of-care (POC) diagnostic technologies where in vitro diagnostics (IVD) is fundamental for prevention, identification, and treatment of many diseases. Over the past decade, a shift of IVDs from the centralized laboratories to POC settings is emerging. In this review, we summarize recent progress in translating IVDs from centralized labs to POC settings using commercially available handheld meters. After introducing typical workflows for IVDs and highlight innovative technologies in this area, we discuss advantages of using commercially available handheld meters for translating IVDs from centralized labs to POC settings. We then provide comprehensive coverage of different signal transduction strategies to repurpose the commercially-available handheld meters, including personal glucose meter, pH meter, thermometer and pressure meter, for detecting a wide range of targets by integrating biochemical assays with the meters for POC testing. Finally, we identify remaining challenges and offer future outlook in this area.

Indexed as

Handheld metersIn vitro diagnosticsPersonal glucose meterPoint-of-Care testingSignal transduction strategies

Identifiers

PMID32194293
PMCPMC7081941

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.