ArticleJournal of ethnopharmacology2020
IL-17A inhibitions of indole alkaloids from traditional Chinese medicine Qing Dai.
Article in Journal of ethnopharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 25 citations in OpenAlex.
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- Total Synthesis of (±)-Baphicacanthcusine A Enabled by Sequential Ring Contractions.Angewandte Chemie (International ed. in English) · 2024Article
- Systematic appraisals of naturally occurring alkaloids from medicinal plants.Naunyn-Schmiedeberg's archives of pharmacology · 2024Review
- Yinxie I Formula attenuates imiquimod-induced psoriasis-like skin inflammation via IL-23/IL-17 axis.Archives of dermatological research · 2024Article
- Exploring the Therapeutic Potential of Natural Compounds in Psoriasis and Their Inclusion in Nanotechnological Systems.Antioxidants (Basel, Switzerland) · 2024Review
- Anti-Atopic Effect of Isatidis Folium Water Extract in TNF-α/IFN-γ-Induced HaCaT Cells and DNCB-Induced Atopic Dermatitis Mouse Model.Molecules (Basel, Switzerland) · 2023Article
- Regulatory effect of gut microbes on blood pressure.Animal models and experimental medicine · 2022Review
- Classic mechanisms and experimental models for the anti-inflammatory effect of traditional Chinese medicine.Animal models and experimental medicine · 2022Review
- Bacterial-Induced Blood Pressure Reduction: Mechanisms for the Treatment of HypertensionFrontiers in cardiovascular medicine · 2021Review
- Photodynamic Therapy of Novel Photosensitizer Ameliorates TNBS-Induced Ulcerative ColitisFrontiers in pharmacology · 2021Article
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7 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
ethnopharmacological relevanceQing Dai, a famous traditional Chinese medicine (TCM), is prepared by a traditional fermentation process with the aerial part of Strobilanthes cusia. Currently, this TCM could treat various clinical inflammatory diseases, such as ulcerative colitis and psoriasis, however, the bioactive components of Qing Dai are unknown clearly. AIM OF THE STUDY: To isolate and identify the anti-IL-17A components of Qing Dai. MATERIALS AND
methodsSilica, RP-18 gels, and size exclusion resin were used for column chromatography to isolate the pure compounds. The structures of isolates were elucidated by NMR, MS, UV, IR spectra, and optical rotation. IL-17A protein and gene expressions were also evaluated in the Th17 cell model and luciferase reporter assay, respectively.
resultsTwo indole alkaloids, including one new indigodole D and cephalandole B, were isolated from Qing Dai. Indigodole D could inhibit IL-17A protein production during the Th17 polarization (EC
conclusionsIndole alkaloids, indigodoles A, C, D, tryptanthrin, and indirubin could contribute to anti-IL 17A properties of Qing Dai. The possible biogenetic mechanisms of above-mentioned indoles were also speculated in this investigation for further promising anti-IL-17 lead drugs development.
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