ArticleBrain research2020
Characterization of tissue and functional deficits in a clinically translational pig model of acute ischemic stroke.
Article in Brain research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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Who cites it
19 citing papers in PubMed, 27 citations in OpenAlex.
- Small bone replacement leads to greater gait asymmetry, cartilage damage, and osteophyte formation than ligament injury in a porcine wrist model.Osteoarthritis and cartilage open · 2026Article
- Spatial and Temporal Assessment of Cerebral Blood Flow in a Novel Piglet Model of Neonatal Arterial Ischemic Stroke.Translational stroke research · 2025Article
- Behavioral tests to assess short- and long-lasting sensorimotor deficits following transient focal cerebral ischemia in rodents.Pharmacological reports : PR · 2025Review
- Development of small bone implants using a mean shape bone in a porcine model for carpal bone replacement.Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine · 2025Article
- Biomechanical evaluation of the porcine carpus as a potential preclinical animal model for the human carpus.Journal of biomechanics · 2024Article
- Early to sustained impacts of lethal radiation on circulating miRNAs in a minipig model.Scientific reports · 2023Article
- Gait analysis in swine, sheep, and goats after neurologic injury: a literature review.Neural regeneration research · 2023Review
- Establishment of a reproducible and minimally invasive ischemic stroke model in swine.JCI insight · 2023Article
- The Ties That Bind: Glial Transplantation in White Matter Ischemia and Vascular Dementia.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023Review
- Neurological scoring and gait kinematics to assess functional outcome in an ovine model of ischaemic stroke.Frontiers in neurology · 2023Article
- Recording of pig neuronal activity in the comparative context of the awake human brain.Scientific reports · 2022Article
- A Swine Hind Limb Ischemia Model Useful for Testing Peripheral Artery Disease Therapeutics.Journal of cardiovascular translational research · 2021Article
- Oleuropein Protects Against Cerebral Ischemia Injury in Rats: Molecular Docking, Biochemical and Histological Findings.Neurochemical research · 2021Article
- Local Experimental Intracerebral Hemorrhage in Rats.Biomedicines · 2021Article
- Exploring the predictive value of lesion topology on motor function outcomes in a porcine ischemic stroke model.Scientific reports · 2021Article
- Treadmill-Based Gait Kinematics in the Yucatan Mini Pig.Journal of neurotrauma · 2020Article
- Relevance of Porcine Stroke Models to Bridge the Gap from Pre-Clinical Findings to Clinical Implementation.International journal of molecular sciences · 2020Review
- Magnetic Resonance Imaging and Gait Analysis Indicate Similar Outcomes Between Yucatan and Landrace Porcine Ischemic Stroke Models.Frontiers in neurology · 2020Article
- Dynamic Changes in the Gut Microbiome at the Acute Stage of Ischemic Stroke in a Pig Model.Frontiers in neuroscience · 2020Article
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
The acute stroke phase is a critical time frame used to evaluate stroke severity, therapeutic options, and prognosis while also serving as a major tool for the development of diagnostics. To further understand stroke pathophysiology and to enhance the development of treatments, our group developed a translational pig ischemic stroke model. In this study, the evolution of acute ischemic tissue damage, immune responses, and functional deficits were further characterized. Stroke was induced by middle cerebral artery occlusion in Landrace pigs. At 24 h post-stroke, magnetic resonance imaging revealed a decrease in ipsilateral diffusivity, an increase in hemispheric swelling resulting in notable midline shift, and intracerebral hemorrhage. Stroke negatively impacted white matter integrity with decreased fractional anisotropy values in the internal capsule. Like patients, pigs showed a reduction in circulating lymphocytes and a surge in neutrophils and band cells. Functional responses corresponded with structural changes through reductions in open field exploration and impairments in spatiotemporal gait parameters. Characterization of acute ischemic stroke in pigs provided important insights into tissue and functional-level assessments that could be used to identify potential biomarkers and improve preclinical testing of novel therapeutics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.