ArticleDigestive diseases and sciences2021
Sleep Characteristics and Rest-Activity Rhythms Are Associated with Gastrointestinal Symptoms Among Adults with Inflammatory Bowel Disease.
Article in Digestive diseases and sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Cognitive Behavioral Therapy for Insomnia May Improve Sleep and Pain in Crohn's Disease: A Waitlist Control Pilot Trial.Inflammatory bowel diseases · 2026Trial
- Circadian Regulation and Pain: A Systematic Review of the Association Between Rest-Activity Rhythm and Pain-Related Outcomes.Clocks & sleep · 2026Review
- The relationship between insomnia and multiple gastrointestinal disorders: a Mendelian randomization study.BMC gastroenterology · 2025Article
- The Bidirectional Relationship Between Sleep and Pain in Crohn's Disease: A Daily Diary Study.Inflammatory bowel diseases · 2025Article
- Review
- Clinical Spectrum and Trajectory of Innovative Therapeutic Interventions for Insomnia: A Perspective.Aging and disease · 2023Article
- Colitis-associated intestinal microbiota regulates brain glycine and host behavior in mice.Scientific reports · 2022Article
- Sleep Deficiency: A Symptoms Perspective: Exemplars from Chronic Heart Failure, Inflammatory Bowel Disease, and Breast Cancer.Clinics in chest medicine · 2022Review
- Biological Clock and Inflammatory Bowel Disease Review: From the Standpoint of the Intestinal Barrier.Gastroenterology research and practice · 2022Review
- Differential Sleep Traits Have No Causal Effect on Inflammatory Bowel Diseases: A Mendelian Randomization Study.Frontiers in pharmacology · 2021Article
- Disrupted Circadian Rest-Activity Cycles in Inflammatory Bowel Disease Are Associated With Aggressive Disease Phenotype, Subclinical Inflammation, and Dysbiosis.Frontiers in medicine · 2021Article
- Inflammatory Bowel Disease and Sleep Disturbance: As Usual, Quality Matters.Digestive diseases and sciences · 2021Article
- The Feasibility of Measuring Sleep and Circadian Characteristics in Adults with Inflammatory Bowel Disease.Western journal of nursing research · 2020Article
- A framework for symptom self-management for individuals with complex health conditions.Nursing outlookArticle
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundSleep disturbance is common in inflammatory bowel disease (IBD) and is associated with poorer quality of life and increased disease activity; however, sleep is a multidimensional process, and little is known about specific sleep characteristics and rest-activity rhythms (RARs) in this population.
aimsThe purposes were to (1) describe sleep characteristics and RARs; (2) compare sleep characteristics and RARs and GI symptoms by disease activity; and (3) describe associations between sleep characteristics, RARs, and GI symptoms among adults with IBD.
methodsWe conducted a cross-sectional study of adults with IBD. We measured sleep characteristics and RARs (continuous wrist actigraphy); GI symptoms (PROMIS-GI); and disease activity (physicians' global assessment). We conducted cosinor and nonparametric analyses to compute RAR variables and bivariate analyses to address the aims.
resultsThe sample included 37 participants [age M = 38 years (SD = 13.8) and 21 (56.8%) female], of whom 23 (60.6%) were in remission. Sleep efficiency [M = 82.91% (SD 5.35)] and wake after sleep onset (WASO) [M = 42.26 min (SD 18.57)] were not associated with disease activity. Inter-daily stability of the RAR was associated with heartburn/reflux (r = - .491, p = .005) and gas/bloating (r = - .469, p = .008). Intra-daily variability of the RAR was associated with heartburn/reflux (r = .421, p = .018).
conclusionsPeople with IBD may have disrupted RARs, which are associated with GI symptoms. Research is needed to improve understanding of these associations and to develop interventions to improve these characteristics in adults with IBD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.