ArticleWorld journal of pediatrics : WJP2020
Polymyxin for the treatment of intracranial infections of extensively drug-resistant bacteria in children after neurosurgical operation.
Article in World journal of pediatrics : WJP, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 19 citations in OpenAlex.
- Integration of Polymyxin-B Hemoadsorption Device into a CRRT Circuit for Endotoxic Septic Shock in a Child: A Case Report.Pediatric reports · 2026Article
- Efficacy analysis of intraventricular/intrathecal polymyxin B sulphate injections in the treatment of Post-neurosurgical CNS infections in neurocritical ill patients: a prospective observational study.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025Observational
- Polymyxin B in The Treatment of Infections Caused by Multidrug-Resistant Gram-Negative Bacteria in Children: A Retrospective Case Series and A Literature Review.Infection and drug resistance · 2025Article
- Post Trauma Acinetobacter Baumanii Meningitis Treatment Approach.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2024Article
- Intrathecal Injection of Polymyxin B in a Child with Meningitis Caused by Carbapenem-ResistantInfection and drug resistance · 2024Article
- Clinical outcomes and risk factors ofFrontiers in cellular and infection microbiology · 2024Article
- Treatment and prognostic risk factors for intracranial infection after craniocerebral surgery.Neurosurgical review · 2023Article
- Bacterial meningitis in children with an abnormal craniocerebral structure.Frontiers in pediatrics · 2023Article
- Intrathecal Injection of Tigecycline and Polymyxin B in the Treatment of Extensively Drug-Resistant IntracranialInfection and drug resistance · 2022Article
- Differential Diagnosis and Hospital Emergency Management for Fastlane Treatment of Central Nervous System Infection Under the COVID-19 Epidemic in Changsha, China.Frontiers in neurology · 2020Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundIncreased meningitis caused by extensively drug-resistant bacillary presents a significant challenge in antibiotic selection. The aim of our study was to evaluate the efficacy and safety of polymyxin in the treatment of post-neurosurgical meningitis due to the extensively drug-resistant bacillary in children.
methodsWe performed a retrospective study on post-neurosurgical meningitis caused by the extensively drug-resistant bacillary in children, who were treated with polymyxin for ≥ 3 days.
resultsAmong five post-neurosurgical meningitis cases that were included, the children were infected by Acinetobacter baumannii (n = 3), Klebsiella pneumonia (n = 1), and Pseudomonas aeruginosa (n = 1). The drug susceptibility test showed that they were extensively drug-resistant bacillary. Two patients received intravenous polymyxin E. Three children received intravenous combined with intraventricular injection of polymyxin B. One patient infected by Klebsiella pneumonia eventually died of septic shock. No serious adverse effects of polymyxin were observed.
conclusionsPolymyxin is a safe and effective therapy for post-neurosurgical, multidrug-resistant bacillary meningitis in children.
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