ArticleMetabolic brain disease2020
Phosphoinositide-3-kinase regulatory subunit 1 gene polymorphisms are associated with schizophrenia and bipolar disorder in the Han Chinese population.
Article in Metabolic brain disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 11 citations in OpenAlex.
- Shared Genetic Architecture Between Endometriosis and Psychiatric Conditions May Explain Comorbidity.medRxiv : the preprint server for health sciences · 2025Article
- Association between MAPK and PI3K/Akt signaling pathway-related gene polymorphisms and migraine.Molecular genetics & genomic medicine · 2024Article
- Incorporating multi-stage diagnosis status to mine associations between genetic risk variants and the multi-modality phenotype network in major depressive disorder.Frontiers in psychiatry · 2023Article
- Identification and discovery of imaging genetic patterns using fusion self-expressive network in major depressive disorder.Frontiers in neuroscience · 2023Article
- Integrated co-expression network analysis uncovers novel tissue-specific genes in major depressive disorder and bipolar disorder.Frontiers in psychiatry · 2022Article
- Classification for psychiatric disorders including schizophrenia, bipolar disorder, and major depressive disorder using machine learning.Computational and structural biotechnology journal · 2022Article
- Identification of Immune Hub Genes Associated With Braak Stages in Alzheimer's Disease and Their Correlation of Immune Infiltration.Frontiers in aging neuroscience · 2022Article
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8 authors at 1 institution in 1 country.
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Abstract
Schizophrenia (SCZ) and bipolar disorder (BD) are severe psychiatric disorders that share many genetic risk factors. This study aimed to investigate the association of phosphoinositide-3-kinase regulatory subunit1 (PIK3R1) gene rs3756668 and rs3730089 polymorphisms with SCZ and BD risks and determine the expression levels of PIK3R1. A total of 548 SCZ cases, 512 BD cases, and 598 healthy controls were included in this study. Single nucleotide polymorphisms (SNPs) were genotyped using the Sequenom MassARRAY platform, and quantitative reverse transcription polymerase chain reaction was conducted to examine the mRNA expression of PIK3R1. The genotypic distribution of rs3756668 in the BD group was significantly different from that in the healthy controls (P = 0.038). After adjustment for gender and age was made, rs3730089 was significantly associated with the risk of SCZ [AA/(AG + GG): OR = 2.25, P
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