Evidence map›Paper›PMID 32193707›Full record

ReviewCurrent gastroenterology reports2020

Gastroparesis in the 2020s: New Treatments, New Paradigms.

Amol Sharma, Michael Coles, Henry P Parkman

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current gastroenterology reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Article
  3. Pan-Gut Dysmotility in Parkinson Disease.Gastroenterology & hepatology · 2025
    Article
  4. Article
  5. Review
  6. Review
  7. Thoracic Spinal Nerve Neuromodulation Therapy for Diabetic Gastroparesis: A Proof-of-Concept Study.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2023
    Article
  8. Review
  9. Ten controversies in gastroparesis and a look to the future.Neurogastroenterology and motility · 2023
    Review
  10. Using an Endoluminal Functional Lumen Imaging Probe (EndoFLIP™) to Compare Pyloric Function in Patients with Gastroparesis to Patients After Esophagectomy.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2023
    Article
  11. Article
  12. Review
  13. Review
  14. Nitric Oxide: From Gastric Motility to Gastric Dysmotility.International journal of molecular sciences · 2021
    Review
  15. Review
  16. Enlightening the frontiers of neurogastroenterology through optogenetics.American journal of physiology. Gastrointestinal and liver physiology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Amol SharmaDivision of Gastroenterology & Hepatology, Medical College of Georgia, Digestive Health Center, Augusta University, 1120 15th St, AD-2226, Augusta, GA, 30912, USA. amosharma@augusta.edu.
Michael ColesDepartment of Medicine, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Henry P ParkmanDivision of Gastroenterology & Hepatology, Lewis Katz School of Medicine, Temple University Hospital, Philadelphia, PA, USA.
Augusta University · USTemple University Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewThis review highlights recent work that will lead to near-term advances in the understanding and treatment of gastroparesis (Gp). RECENT

findingsMajor current advancements in the pathophysiology of Gp, include recognition of the SIP syncytium as the pacemaking unit rather than ICC alone and that Gp may be part of a pan-enteric autoimmune and/or autonomic disorder with macrophage imbalance. The development of newer techniques to assess gastric emptying (gastric emptying breath test and wireless motility capsule) and pyloric distensibility (EndoFLIP®) are allowing clinicians better characterization of their patients. In addition to pharmaceutical compounds in the pipeline, neuromodulation and endosurgical techniques, such as G-POEM, may help address refractory Gp. We expect that the 2020 decade will witness exciting developments. Treatments targeting gastrointestinal motility, immunological dysfunction, and inflammatory mediators will be evaluated. We anticipate future studies will be guided by biomarkers correlated with patient outcomes and therapeutic efficacy to establish new paradigms in the management of Gp.

Indexed as

BiomarkersBreath TestsCapsule EndoscopyGastric EmptyingGastrointestinal MotilityGastroparesisHumansPyloromyotomyBiomarkersGastric emptying breath testGastric emptying scintigraphyGastroparesisNeuromodulationPro-motility agentsWireless motility capsule

Identifiers

PMID32193707
OpenAlexW3011802813

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.